Clin2
NCT07507526Possibly a fitNot yet recruiting

New drug combo for advanced stomach cancer

Gastric Adenocarcinoma

Part of Cancer, Digestive system clinical trials.

This trial tests a combination of three drugs (Disitamab Vedotin, Tunlametinib, and a PD-1 antibody) for advanced stomach cancer that has HER2 protein. It is for patients who have tried at least two prior treatments or cannot tolerate standard therapy.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
76 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have advanced stomach cancer and have already tried at least two prior treatments (or cannot tolerate them).
  • Your tumor has a high level of HER2 protein (2+ or 3+ on a lab test).
  • You have at least one measurable tumor that can be seen on scans.
  • You are 18 years or older.
  • You have adequate organ function (kidney, liver, blood counts).
  • You have not taken Disitamab Vedotin as your first or second treatment.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07490990Not yet recruiting· Phase 2
Drug combo and targeted radiation for advanced stomach cancer

This trial tests a new drug combination (disitamab vedotin and sintilimab) plus radiation for people with HER2-positive advanced stomach cancer that has worsened after two prior treatments. The goal is to see if this approach can shrink tumors and help patients live longer.

NCT07194005Recruiting· Phase 2
Combination therapy for HER2 1+/2+ advanced stomach cancer

This trial tests a new combination of drugs (RC48, sintilimab, and SOX chemotherapy) for people with stomach or gastroesophageal junction cancer that cannot be removed by surgery, has not been treated before, and has a specific HER2 score (1+ or 2+). The goal is to shrink the tumor enough to possibly allow surgical removal.

Shanghai, Shanghai Municipality
NCT06577376Not yet recruiting· Phase 1/Phase 2
New drug combo for stomach cancer with HER2

This study tests a new combination of targeted therapy (DP303c) with either a drug called simmitinib or a liposomal form of irinotecan for people with advanced stomach or GEJ cancer. The goal is to see if these combinations can shrink tumors or slow cancer growth.

NCT06572319Recruiting· Phase 1/Phase 2
Combination drug trial for HER2-positive stomach cancer

This trial tests two drugs, disitamab vedotin and trastuzumab, for people with HER2-positive stomach or gastroesophageal junction cancer that has spread or come back after at least one prior treatment. The goal is to see if this combination can help shrink tumors.

Hangzhou, Zhejiang
NCT06748508Not yet recruiting· Phase 2
Comparing 3 drug combos for advanced stomach cancer

This trial tests whether adding immunotherapy (sintilimab) to chemotherapy with or without lenvatinib helps people with HER2-negative stomach cancer that has spread. It compares three different treatment combinations to find the best option.

Shanghai, Shanghai Municipality
NCT06932068Recruiting· Phase 2
Study of new drug combo for advanced stomach cancer

This trial tests a combination of two immunotherapy drugs (iparomlimab/tuvonralimab) plus chemotherapy (XELOX) in people with advanced stomach or gastroesophageal junction cancer that is HER2-negative and has low PD-L1 levels. It aims to see if this treatment can help shrink tumors or slow the disease.

Zhengzhou, Henan

Hear when a new Gastric Adenocarcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.