New drug combination for NK/T-cell lymphoma with immune complications
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a combination of five drugs to treat a rare blood cancer called NK/T-cell lymphoma that has triggered an abnormal immune response (hemophagocytic lymphohistiocytosis). The goal is to control both the cancer and the harmful immune reaction.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Diagnosed with extranodal NK/T-cell lymphoma confirmed by biopsy
- Meet at least 5 criteria for hemophagocytic lymphohistiocytosis (a condition where immune cells attack your own blood cells)
- Age 18 or older
- Healthy heart function with ejection fraction of 50% or higher
- No active bleeding, uncontrolled infections, or other cancers
- Negative for HIV, hepatitis C (or controlled if positive), and hepatitis B (or very low viral load if positive)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of three drugs (sintilimab, pegaspargase, and GemOx) for people with a type of lymphoma called extranodal NK/T-cell lymphoma (ENKTL) that hasn't been treated before. The goal is to see if this combination helps control the disease.
This trial tests if adding a new targeted drug (golidocitinib) to standard chemotherapy plus immunotherapy works better than the standard combo alone for people with advanced or non-nasal NK/T-cell lymphoma that hasn't been treated yet.
This trial studies whether sugemalimab (or a placebo) added to a chemotherapy plan can better control extranodal NK/T-cell lymphoma that has come back or didn’t respond to previous treatment. It may help patients by improving the chance of shrinking the tumor and extending how long the disease stays under control.
This trial compares an immunotherapy approach to standard chemotherapy as a first step before stem cell transplant for patients with advanced NK/T-cell lymphoma. It aims to see which treatment helps patients better before their own stem cells are transplanted.
This trial tests a new combination of medicines (the GO regimen) for people with hemophagocytic lymphohistiocytosis (HLH) that is either newly diagnosed, has come back, or hasn't responded to other treatments. It aims to see if this approach can help when a stem cell transplant isn't an option right now.
This trial tests a new combination of drugs (chidamide, an anti-PD-1 antibody, and pegaspargase) against a standard treatment for people with advanced-stage, newly diagnosed NK/T-cell lymphoma. It aims to see if the new combination works better and is safe.
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