Vaginal estradiol versus moisturizer for menopause symptoms in women with HIV
Part of Immune system & allergy, Infections, Women’s health & pregnancy clinical trials.
This study compares a vaginal estradiol tablet (Vagifem) to a moisturizer to see which works better for treating vaginal dryness, irritation, and related urinary symptoms in women living with HIV who have gone through menopause. The study also looks at how each treatment affects the healthy bacteria in the vagina.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are female, at least 40 years old
- You have not had a period for at least 12 months (or are in late menopause transition with 60+ days without a period) AND this happened within the last 2 years
- You have vaginal symptoms like dryness, soreness, itching, or pain during sex that started within the last 2 years—OR urinary symptoms like urgency, frequent urination, or recurrent urinary tract infections
- You have not had pelvic or vaginal surgery in the past 2 months, and you're not actively trying to get pregnant or currently pregnant
- You haven't used hormonal medications, antibiotics, immunosuppressants, or vaginal products in the recent past (timeline varies by medication)
- You do not have a history of breast cancer, blood clots, heart attack, stroke, severe liver disease, or known bleeding disorders
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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