Safety study of crinecerfont for very young children with CAH
Part of Genetic & congenital, Hormones & metabolism, Kidney & urinary, Women’s health & pregnancy clinical trials.
This study tests a new medicine called crinecerfont in children under 4 years old with classic congenital adrenal hyperplasia (CAH), a condition where the body doesn't make certain hormones properly. Researchers want to learn if the medicine is safe and how it works in the body.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Child must be diagnosed with classic CAH caused by 21-hydroxylase deficiency (a specific genetic problem affecting hormone production)
- Child must weigh at least 4.5 kilograms (about 10 pounds)
- Child must have been taking hydrocortisone (a steroid replacement) for at least 3 months, with the same dose for at least 4 weeks before enrollment
- Child's newborn screening test must show either elevated 17-OHP levels or other findings that a pediatric specialist has evaluated and cleared
- Child cannot have other forms of CAH or other conditions requiring daily steroid therapy
- Child cannot have other serious medical conditions or chronic diseases
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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