Gold nanoparticles and radiation therapy for advanced melanoma
Treatments studied
Part of Cancer, Skin clinical trials.
This study tests a new treatment combining gold nanoparticles (Au-TMP), radiation therapy, and an immune-boosting drug (anti-PD-1) for advanced melanoma that cannot be surgically removed. The goal is to help your immune system fight the cancer more effectively.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and in good enough health to tolerate treatment (ECOG score 0–1, meaning you can do most daily activities)
- You have advanced melanoma (Stage III or IV) that has not been treated with systemic therapy before, though prior adjuvant or neoadjuvant therapy is okay if finished 3+ weeks ago
- You have at least one tumor lesion that can be injected with the gold nanoparticles and treated with radiation (in skin, fat layer, lymph nodes, or accessible internal organs)
- Your blood cell counts, kidney function, liver function, and heart function are adequate based on recent lab tests
- You have never received anti-PD-1 or anti-PD-L1 immunotherapy before
- You are willing to use effective contraception during the study and for 12 months after treatment ends
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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