DHEA vs Estradiol for Vaginal Symptoms After Menopause
Part of Kidney & urinary, Mental health, Women’s health & pregnancy clinical trials.
This study compares two vaginal treatments—DHEA and estradiol—to help relieve common menopause symptoms like dryness, itching, or discomfort during sex. You'll use vaginal therapy (applied directly where symptoms occur) and help researchers understand which works better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are in perimenopause or postmenopause (the years around or after your final period)
- You have at least one vaginal or genitourinary symptom, such as dryness, itching, discomfort, or pain during intercourse
- You are willing and able to use vaginal therapy as directed
- You have not used systemic hormone therapy (pills, patches, or shots affecting your whole body) in the past 6 months
- You have no history of gynecologic cancer or pelvic radiation therapy
- You speak English and can provide informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether vaginal estrogen or platelet-rich plasma (PRP) works better to relieve genital and urinary symptoms caused by menopause. You may be able to try one of these treatments as part of a study aimed at improving comfort and function.
This study tests a new vaginal moisturizer for menopausal women with vaginal dryness. The goal is to see how well it hydrates the skin and is accepted by your body, and you'll be asked to use it and report how you feel.
This study tests a testosterone gel applied to the skin to see if it helps women in perimenopause or postmenopause who have low sexual interest and arousal. It aims to find a new treatment option for this condition.
This trial is testing a new non-hormonal gel for vaginal dryness and discomfort after menopause. It aims to see if the gel improves quality of life.
This trial tests a cream made from wheat polar lipids to see if it helps with vaginal dryness after menopause. It may offer a non-hormonal option for women with moderate to severe discomfort.
This study compares a vaginal estradiol tablet (Vagifem) to a moisturizer to see which works better for treating vaginal dryness, irritation, and related urinary symptoms in women living with HIV who have gone through menopause. The study also looks at how each treatment affects the healthy bacteria in the vagina.
Hear when a new Post-menopause trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.