Fetal Treatment for Congenital Diaphragmatic Hernia
Part of Genetic & congenital clinical trials.
This trial tests a procedure called FETO (fetoscopic endoluminal tracheal occlusion) performed during pregnancy to help babies with congenital diaphragmatic hernia—a birth defect where part of the diaphragm (breathing muscle) has a hole and organs from the belly move into the chest. The procedure temporarily blocks the baby's windpipe to help the lungs grow bigger before birth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are pregnant with one baby (not twins or multiples) and are 18 years or older
- Your baby has been diagnosed with congenital diaphragmatic hernia with liver herniation into the chest, confirmed by ultrasound
- You are before 29 weeks and 6 days of pregnancy at the time of enrollment
- Your baby's genetic testing (karyotype or chromosomal microarray) shows no other genetic abnormalities that would affect survival
- If choosing the FETO procedure: you can live within 30 minutes of Von Voigtlander Women's Hospital and have a support person available to stay with you for the remainder of your pregnancy
- You are willing to follow activity restrictions (no exercise, intercourse, or work outside the home for the duration of pregnancy)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies a fetal procedure called FETO that places a small balloon in the baby’s windpipe to help the lungs grow in severe congenital diaphragmatic hernia (CDH). It may help babies with very small lung development after birth, but you must meet specific pregnancy, genetic, and safety requirements.
This trial tests a special pregnancy procedure called FETO to help babies born with severe congenital diaphragm hernia (CDH) breathe better after birth. It may help by improving lung growth, but it requires close follow-up at a Chicago fetal center.
This trial tests if a special surgery (FETO) done while the baby is still in the womb can improve survival for babies with a severe form of congenital diaphragmatic hernia (CDH). The surgery places a small balloon in the baby's windpipe to help the lungs grow. We are looking for pregnant women whose baby has a left-sided CDH with a lung-to-head ratio (LHR) less than 30%, or a right-sided CDH with LHR less than 45%, and whose liver is herniated into the chest.
This trial studies a fetal procedure called FETO (placing a small balloon in the baby’s windpipe) to help severe congenital diaphragmatic hernia babies develop better lungs before birth. It may help some babies whose scans suggest very limited lung growth, but it requires specific timing and pregnancy conditions.
This trial tests a procedure called fetoscopic tracheal occlusion to improve lung growth in babies with a severe diaphragmatic hernia. It is for pregnant women carrying a single baby with certain types of this condition, and the goal is to see if the procedure is safe and effective.
This study tests a fetal surgery (fetoscopic tracheal balloon placement) to help lungs grow in babies with a severe hole in the diaphragm. It focuses on pregnancies where the liver is also in the chest and lung size is very small.
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