Fetoscopic surgery for severe diaphragmatic hernia
Part of Genetic & congenital, Heart & circulation, Lungs & breathing clinical trials.
This trial tests if a special surgery (FETO) done while the baby is still in the womb can improve survival for babies with a severe form of congenital diaphragmatic hernia (CDH). The surgery places a small balloon in the baby's windpipe to help the lungs grow. We are looking for pregnant women whose baby has a left-sided CDH with a lung-to-head ratio (LHR) less than 30%, or a right-sided CDH with LHR less than 45%, and whose liver is herniated into the chest.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old and pregnant with one baby.
- Your baby has a severe left or right diaphragmatic hernia (a hole in the muscle that separates the chest and belly).
- The baby's liver is pushed up into the chest (liver herniation).
- You must be less than 29 weeks and 6 days pregnant when you join the trial.
- You are able to stay near the hospital (within 30 minutes) for the rest of your pregnancy and have a support person with you.
- You do not have any condition that makes the surgery unsafe, like a short cervix, placenta problems, or certain infections (HIV, hepatitis B or C).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies a fetal procedure called FETO (placing a small balloon in the baby’s windpipe) to help severe congenital diaphragmatic hernia babies develop better lungs before birth. It may help some babies whose scans suggest very limited lung growth, but it requires specific timing and pregnancy conditions.
This trial tests a procedure called fetoscopic tracheal occlusion to improve lung growth in babies with a severe diaphragmatic hernia. It is for pregnant women carrying a single baby with certain types of this condition, and the goal is to see if the procedure is safe and effective.
This study tests a fetal surgery (fetoscopic tracheal balloon placement) to help lungs grow in babies with a severe hole in the diaphragm. It focuses on pregnancies where the liver is also in the chest and lung size is very small.
This trial studies a specialized pregnancy procedure (FETO) done to help babies with a defect in the diaphragm called congenital diaphragmatic hernia (CDH) grow better lungs before birth. It may help by improving lung development, based on how severe the baby’s lung underdevelopment looks on ultrasound, and it requires close follow-up at the study hospital.
This trial tests a procedure called FETO (fetoscopic endoluminal tracheal occlusion) performed during pregnancy to help babies with congenital diaphragmatic hernia—a birth defect where part of the diaphragm (breathing muscle) has a hole and organs from the belly move into the chest. The procedure temporarily blocks the baby's windpipe to help the lungs grow bigger before birth.
This study follows babies born after a special fetal surgery (FETO) that places a temporary balloon in the baby's windpipe to help the lungs grow when they have a diaphragmatic hernia—a hole in the muscle that separates the chest from the belly. Researchers want to understand how these children do over time after this procedure.
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