How Weight Loss Medicine Affects Brain Health and Blood Vessels
Treatments studied
Part of Hormones & metabolism clinical trials.
This study examines how semaglutide (a weight loss injection) affects brain function and blood vessel health in people with obesity. Researchers will compare brain scans and blood vessel measurements before and after treatment to understand whether weight loss improves thinking and memory.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 35 and 55 years old
- Have a BMI (body weight relative to height) between 27 and 40, or be a lean control with BMI 20–25
- Not have type 2 diabetes or neurological disorders
- Not be on certain brain-active medications or have poorly controlled depression or suicidal thoughts
- Be willing to self-inject semaglutide weekly and attend study visits for the entire trial
- Not have had pancreatitis, bariatric surgery, or used other weight loss medications in the past 90 days
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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