Saliva markers for predicting reflux after weight-loss surgery
Part of Cancer, Digestive system clinical trials.
This study looks at whether bile acids and pepsin in saliva can predict acid reflux after sleeve gastrectomy, a weight-loss surgery. If you're planning this surgery, researchers will take saliva samples to see if they can identify who might develop reflux, which could help with earlier treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- You need to be scheduled for a sleeve gastrectomy (weight-loss surgery) at a participating hospital.
- Your body mass index (BMI) must be 50 or lower.
- You need to have no prior diagnosis of severe acid reflux disease, including erosive esophagitis, a narrowed esophagus, or Barrett's esophagus.
- You must not have had any previous surgery on your esophagus.
- You need to avoid certain medications that affect bile acids (like bile acid sequestrants or ursodeoxycholic acid) within one month before saliva samples, and avoid antibiotics within four weeks before samples.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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