Treatments for persistent headache after head injury
Treatments studied
Part of Brain & nervous system, Pain clinical trials.
This study compares three treatments for persistent headaches that start after a head injury: a nerve-stimulating device (gammaCore), a cannabis-derived product (CBD), and standard care. It aims to see which treatment works best to reduce headache days and pain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have had a head injury that caused persistent headaches lasting more than 3 months.
- You have between 4 and 25 headache days per month (with at least 4 of them being moderate or severe).
- You are willing to keep a daily headache diary for 28 days and complete the study visits.
- You agree to be randomly assigned to one of the three treatments and to follow the study rules.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at treatment for ongoing headache that starts or gets worse after a mild or moderate head/neck injury in veterans or active-duty service members. It may help by testing an approach aimed at reducing headache burden and improving daily functioning.
This study compares two non-drug treatments for people with persistent headaches that started or worsened after a mild head injury (concussion). One treatment is behavior therapy, which teaches skills to manage pain, and the other is education about headaches. The goal is to see which approach helps more.
This trial studies whether cannabis can reduce chronic migraine headaches in adolescents who have not improved with other treatments. It also asks participants to work with psychology and physiotherapy during the study.
This study tests whether combining mindfulness training with a small nerve-stimulating earbud can reduce headaches in people who had a mild brain injury. It aims to see if this approach helps with pain and daily function.
This trial tests whether people with long-term headache after a mild head injury have an abnormal reaction to a substance called adrenomedullin, which may play a role in causing headaches. You will receive adrenomedullin and a placebo in separate sessions to see how your headache responds.
This trial tests if Botox injections can reduce headache days in people with persistent headaches after a mild head injury. It may help if you have headaches at least 15 days a month.
Hear when a new Persistent Post Traumatic Headache trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.