Studying sensitivity to adrenomedullin in chronic post-traumatic headache
Part of Brain & nervous system, Pain clinical trials.
This trial tests whether people with long-term headache after a mild head injury have an abnormal reaction to a substance called adrenomedullin, which may play a role in causing headaches. You will receive adrenomedullin and a placebo in separate sessions to see how your headache responds.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old
- You have had a persistent headache for at least 12 months after a mild head injury, with at least 4 headache days per month
- You have had only one mild head injury and no other head or neck injuries
- You have no history of other headache disorders before the head injury, except for occasional tension headaches
- You do not have any heart or blood vessel disease, or uncontrolled high or low blood pressure
- You have not taken any headache medication within 2 days before the study infusion, and your headache at the start is mild (no more than 3 out of 10)
- You are willing to not change your preventive headache medications for 2 months before and during the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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