Studying sensitivity to adrenomedullin in chronic post-traumatic headache
Part of Brain & nervous system, Pain clinical trials.
This trial tests whether people with long-term headache after a mild head injury have an abnormal reaction to a substance called adrenomedullin, which may play a role in causing headaches. You will receive adrenomedullin and a placebo in separate sessions to see how your headache responds.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old
- You have had a persistent headache for at least 12 months after a mild head injury, with at least 4 headache days per month
- You have had only one mild head injury and no other head or neck injuries
- You have no history of other headache disorders before the head injury, except for occasional tension headaches
- You do not have any heart or blood vessel disease, or uncontrolled high or low blood pressure
- You have not taken any headache medication within 2 days before the study infusion, and your headache at the start is mild (no more than 3 out of 10)
- You are willing to not change your preventive headache medications for 2 months before and during the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if Botox injections can reduce headache days in people with persistent headaches after a mild head injury. It may help if you have headaches at least 15 days a month.
This study looks at treatment for ongoing headache that starts or gets worse after a mild or moderate head/neck injury in veterans or active-duty service members. It may help by testing an approach aimed at reducing headache burden and improving daily functioning.
This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
This study checks if a natural substance called amylin might make your headache worse after a head injury. The researchers will see how your body reacts to amylin compared to a placebo, which could help find new treatments.
This trial tests a substance that activates adrenomedullin receptors, which may be a new way to treat migraines. It may help people who have migraines without aura and aren't on preventive migraine medications.
This study tests whether a natural chemical called substance P can trigger headaches in healthy people, to help researchers understand why some people get migraines. You'll receive an infusion and be monitored for any headache response — your participation could help improve future migraine treatments.
Hear when a new Posttraumatic Headache trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.