Targeted therapy with chemotherapy for recurrent IDH-mutant glioma
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This trial tests a combination of two oral medications (vorasidenib and lomustine) for people whose brain tumor (glioma) has come back and has an IDH1 or IDH2 mutation. The goal is to see if this combination is safe and effective in halting or slowing tumor growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have a recurrent (returned) brain tumor called a glioma that is grade 2, 3, or 4, and has a specific genetic change called an IDH1 or IDH2 mutation.
- You must have had at least one prior treatment such as surgery, radiation, or chemotherapy.
- You must be able to take oral (by mouth) medications and swallow pills.
- You must have adequate organ function (kidney, liver, blood counts) and be reasonably active (Karnofsky score 60% or higher).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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