Clin2
NCT07639099Possibly a fitNot yet recruiting

Nasal spray to reduce depression after childbirth

ParturientsDepressive SymptomsEsketamineDexmedetomidineIntranasal AdministrationPostpartum Depression

Part of Mental health, Women’s health & pregnancy clinical trials.

This study tests whether giving two medicines as a nasal spray around the time of childbirth can help prevent or reduce postpartum depression. It may help women who already have some depression symptoms during pregnancy feel better after giving birth.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
164 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be at least 18 years old and pregnant, planning to give birth.
  • You must have some symptoms of depression during pregnancy (a score of 5 or more on a standard depression questionnaire).
  • You must not have certain serious pregnancy complications (like severe preeclampsia or placenta problems).
  • You must not have severe heart disease, uncontrolled high blood pressure, or an overactive thyroid.
  • You must not have a slow heart rate or certain heart rhythm problems, or significant nasal blockages.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06767566Recruiting· Phase 1
Ketamine for depression and pain after cesarean delivery

This study tests whether ketamine, a medicine given during cesarean delivery, can help prevent or reduce postpartum depression and pain. It aims to find the best dose for new mothers.

Pittsburgh, Pennsylvania
NCT07298525Not yet recruiting· Phase 4
Comfort before anesthesia with a nasal spray

This trial tests a nasal spray that helps you feel calm and relaxed before anesthesia for your surgery. It may be an option for people having general anesthesia or other types of anesthesia, and the study checks if it is safe and works well.

NCT07501728Not yet recruiting
Nasal medication to help prevent postpartum depression

This study tests whether a medication given as a nasal spray during labor can lower the chance of developing depression after childbirth. It may help women who are having a planned vaginal delivery with pain relief.

Chengdu, Sichuan
NCT06103760Recruiting· Phase 4
Esketamine for hard-to-treat depression

This study tests whether esketamine, a nasal spray for depression, can help adults whose depression has not improved with at least two other antidepressants. Participants continue their current treatment while receiving esketamine.

St Leonards, New South Wales
NCT07716098Recruiting· Phase 3
Esketamine nasal spray for treatment-resistant depression

This study tests esketamine nasal spray versus a placebo in adults with depression that has not improved after trying at least two other antidepressants. It aims to see if the spray can help when standard pills have not worked.

Redlands, California
NCT06665568Not yet recruiting· Early Phase 1
Ketamine nasal spray for depression and anxiety in advanced cancer

This study tests whether a ketamine nasal spray can help reduce depression and anxiety in people with advanced cancer. It also looks at how caregivers are affected. If you are living with progressive cancer and feeling down or anxious, this treatment might offer some relief.

Zurich, Canton of Zurich

Hear when a new Depressive Symptoms trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.