Esketamine for hard-to-treat depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether esketamine, a nasal spray for depression, can help adults whose depression has not improved with at least two other antidepressants. Participants continue their current treatment while receiving esketamine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with major depressive disorder and are currently depressed.
- You have tried at least two different antidepressants at the right dose and duration, but they didn't work well enough.
- You are willing to keep taking your current antidepressant or continue therapy during the study.
- You are not pregnant, breastfeeding, or planning to become pregnant, and you agree to use effective birth control.
- You do not have certain other mental health conditions, such as bipolar disorder, schizophrenia, or a current substance misuse problem.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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