Pirfenidone and immunotherapy with optional radiation for advanced colorectal cancer
Part of Cancer, Digestive system clinical trials.
This study tests a combination of three treatments—pirfenidone (an anti-scarring drug), a PD-1 inhibitor (an immunotherapy that helps your immune system fight cancer), and sometimes radiation—for colorectal cancer that has stopped responding to standard treatments. The goal is to see if this combination can slow or shrink your cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Confirmed colorectal cancer that is advanced or has spread, with a specific genetic marker (MSS or pMMR status)
- Cancer has progressed despite standard treatment, or you are unable to tolerate or access standard options
- Age between 18 and 75 years old
- Blood work, liver function, kidney function, and clotting tests must be within safe ranges (tests done within 7 days before starting)
- Good overall health and ability to perform daily activities (ECOG score 0 or 1)
- No active brain tumors, seizures, spinal cord compression, or serious heart/lung disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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