A study of CS-121 for severe high triglycerides
Treatments studied
Part of Hormones & metabolism clinical trials.
This trial tests an experimental drug called CS-121 for people with very high triglyceride levels that don't improve with standard treatments. It uses a new gene-editing approach to lower triglycerides and aims to reduce the risk of pancreatitis and other complications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 64 years old.
- Your triglycerides are very high (≥500 mg/dL) despite trying standard treatments, and you have had at least 3 high readings in the last 2 years.
- You must have two separate high triglyceride readings at least a week apart during screening.
- You agree to use effective contraception if you or your partner can have children, and women must not be pregnant or breastfeeding.
- You do not have serious liver, kidney, or blood problems, or a recent history of pancreatitis, heart attack, or certain infections.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new injectable drug called DR10624 for people with very high triglyceride levels. It aims to lower triglycerides and reduce the risk of pancreatitis (inflammation of the pancreas).
This trial tests a new medicine, CTX310, for people with persistently high levels of fats (triglycerides) and cholesterol that have not improved with standard treatments. It aims to see if the drug is safe and tolerable.
This study tests a new gene-editing treatment called CS-121 for people with FCS whose triglycerides remain very high despite standard therapy. It aims to lower triglyceride levels by editing the APOC3 gene.
This trial tests two experimental drugs, HRS-7249 and SHR-1918, to lower very high triglyceride levels in people who are at high risk for pancreatitis. It aims to see if these drugs can reduce the risk of pancreatitis attacks.
This trial tests a new drug, DR10624, to see if it can lower high triglycerides and reduce plaque in the carotid artery (the main artery in your neck). It may help people with both conditions who are also overweight.
This trial tests a new gene-editing treatment (CS-121) for children and teens with a rare inherited condition called Familial Chylomicronemia Syndrome (FCS). It aims to lower very high triglyceride levels and reduce the risk of pancreatitis.
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