Zoledronate for pain in children with chronic recurrent multifocal osteomyelitis
Treatments studied
Part of Bones, joints & muscles, Infections clinical trials.
This trial tests whether zoledronate, a medicine that helps strengthen bones, can reduce pain in children with a rare bone condition called chronic recurrent multifocal osteomyelitis (CRMO). It compares zoledronate to a placebo (a dummy treatment) to see if it works better at easing pain after 12 weeks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 4 and 17 years old.
- You have been diagnosed with CRMO by a doctor, with signs of active disease on an MRI within the last 12 weeks.
- You have had pain (scored at least 30 out of 100) despite taking anti-inflammatory drugs (NSAIDs) for at least 4 weeks.
- You have had a dental check-up within the last 3 months, and any needed dental work is done before starting the study drug.
- You have not taken bisphosphonates (like zoledronate) or certain other biologic medicines in the last 6 months.
- You do not have conditions like low calcium, severe kidney problems, or a history of seizures, cancer, or certain infections.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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