Study of a new drug combo for advanced stomach cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests a new drug called ASP2138 combined with chemotherapy and pembrolizumab for people with advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery or has spread. It may help if your tumor has certain markers (CLDN18.2 and PD-L1) and you haven't had prior chemotherapy for advanced disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery or has spread.
- Your tumor must test positive for a protein called CLDN18.2, and also have a PD-L1 result from a central lab.
- You can still be physically active (ECOG score 0 or 1) and expected to live at least 12 weeks.
- You should not have had prior chemotherapy or immunotherapy for your advanced cancer, except maybe one cycle of certain chemos before joining.
- You cannot have other serious illnesses like heart disease, uncontrolled high blood pressure, bleeding problems, or active infections.
- You must agree to use effective contraception if you or your partner could become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This Phase 1 trial tests ASP2138 alone or with other cancer medicines in adults with stomach (including GEJ) or pancreatic cancer. You may be eligible if your tumor has a specific protein marker and your health tests and scan results meet safety requirements.
This study tests a combination of two experimental drugs (QLS31905 and QL2107) plus chemotherapy (oxaliplatin and capecitabine) as the first treatment for advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery. The goal is to see if the combination helps shrink tumors and control the cancer better than standard care.
This trial tests a new combination of immunotherapy drugs (AK129 and cadonilimab) plus chemotherapy for people with advanced stomach or GEJ cancer who have not had treatment before. The goal is to see if adding these immunotherapies helps shrink tumors or slow cancer growth better than chemotherapy alone.
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This trial tests a new immunotherapy drug called cadonilimab combined with chemotherapy for people with advanced stomach cancer that hasn't been treated yet. It compares this combination to chemotherapy with or without another immunotherapy drug, nivolumab.
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