Clin2
NCT07680764Possibly a fitRecruiting

Imzokitug plus pumitamig and chemo for first-line advanced lung cancer

Locally Advanced Non-Small Cell Lung Cancer (NSCLC)Metastatic Non-Small Cell Lung Cancer (NSCLC)

Treatments studied

Part of Cancer, Lungs & breathing clinical trials.

This trial tests a new combination of drugs (imzokitug, pumitamig, and platinum-doublet chemotherapy) as a first treatment for advanced or metastatic non-small cell lung cancer that has not spread to the brain. The goal is to see if adding imzokitug makes the standard treatment work better.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
160 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have stage IV or recurrent non-small cell lung cancer that cannot be removed with surgery
  • You have not had any previous cancer treatment for advanced or metastatic disease
  • You have a tumor sample (fresh or within the last 5 months) that can be tested
  • You are able to perform daily activities without much help (ECOG 0 or 1)
  • You have at least one tumor that can be measured on scans
  • You do not have a gene mutation that can be treated with a targeted therapy already available

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06712316Recruiting· Phase 2/Phase 3
New drug plus chemotherapy for advanced lung cancer

This trial tests a new investigational drug combined with chemotherapy for people with advanced non-small cell lung cancer that has not been treated before. The goal is to see if it is safe and works better than current treatments.

Birmingham, Alabama
NCT06841055Recruiting· Phase 2
Pumitamig plus chemo for Stage IV lung cancer after immunotherapy

This trial tests a new investigational drug called Pumitamig (BNT327) given with chemotherapy for people with advanced non-small cell lung cancer (Stage IV) that has continued to grow after one prior treatment with immunotherapy and platinum chemotherapy. The study aims to see if this combination is safe and can help shrink the cancer.

Birmingham, Alabama
NCT06969612Recruiting· Phase 1
New drug combo as first treatment for advanced lung cancer

This trial tests a new combination of three medicines (Golidocitinib, Tislelizumab, and chemotherapy) as the first treatment for advanced non-small cell lung cancer (NSCLC). It is designed for people whose tumors have at least 1% PD-L1 and who have not had any previous treatment for advanced disease.

Beijing, Beijing Municipality
NCT07361510Recruiting· Phase 3
Pumitamig vs Keytruda for advanced lung cancer with high PD-L1

This trial compares an experimental drug called Pumitamig with the approved immunotherapy drug Pembrolizumab (Keytruda) as the first treatment for advanced lung cancer that has high PD-L1 levels. The goal is to see which drug works better and has fewer side effects.

Daphne, Alabama
NCT07111520Recruiting· Phase 1/Phase 2
Combination treatment for advanced lung cancer

This trial tests two investigational drugs, BNT326 and BNT327, together in people with advanced non-small cell lung cancer (NSCLC) that has spread or can't be cured with local treatment. The goal is to see if the combination is safe and might help shrink tumors.

Los Angeles, California
NCT07486817Recruiting· Phase 2
Testing zongertinib with chemo and immunotherapy for advanced lung cancer

This trial tests a new drug called zongertinib combined with chemotherapy, with or without pembrolizumab (an immunotherapy), for people with advanced non-small cell lung cancer that has a specific change in the HER2 gene. The goal is to see how safe and well-tolerated the combination is.

St Leonards, New South Wales

Hear when a new Locally Advanced Non-Small Cell Lung Cancer (NSCLC) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.