Zanidatamab and chemotherapy before surgery for HER2-positive stomach cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests whether a targeted drug (zanidatamab, which attacks HER2-positive cancer cells) combined with chemotherapy can shrink stomach cancer before surgery, making it easier to remove. It may also help people whose cancer has spread a bit, by making it operable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have HER2-positive stomach or gastroesophageal junction cancer (a specific protein marker).
- Your cancer must be stage 3 (advanced but not spread far), or stage 4 with limited spread (like to the liver or lymph nodes).
- You have not had chemotherapy or targeted therapy for this cancer before.
- You are between 18 and 75 years old and in fairly good health (able to do light activity).
- Your major organs (like liver, kidneys, blood cells) need to be working well enough for surgery.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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