Short radiation followed by combo therapy for HER2+ stomach cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a new approach for stomach cancer that has spread to nearby tissues but not to other organs. You would get a short course of radiation, followed by a combination of targeted therapy (Disitamab Vedotin), chemotherapy (S-1), and immunotherapy (Sintilimab) before surgery to shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stomach or gastroesophageal junction cancer that has spread locally but is still removable by surgery.
- Your tumor tests positive for HER2 (a protein that helps cancer grow), with a score of 1+, 2+, or 3+.
- You are between 18 and 75 years old and have good overall health (ECOG score 0 or 1).
- You have not had previous treatment for this cancer, such as radiation, chemotherapy, or immunotherapy.
- You are willing to use effective contraception if you could become pregnant, and you are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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