Psilocybin and therapy for depression with trauma
Treatments studied
Part of Injuries & trauma, Mental health clinical trials.
This trial tests psilocybin (a compound from certain mushrooms) combined with a structured therapy to see if it helps people with depression linked to trauma. It focuses on how the treatment affects the connection between the gut and brain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 60 years old.
- You have been diagnosed with major depression and also have significant trauma-related symptoms.
- You are currently taking only one antidepressant (an SSRI) and have been on it for at least 6 weeks.
- You do not have a history of bipolar disorder, psychosis, or a current substance use problem.
- You are willing to attend all study visits and follow safety guidelines, including using contraception if applicable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a type of therapy that uses psilocybin (a safe, natural substance found in certain mushrooms) to help people with PTSD. It combines talk therapy with the medicine to see if it can reduce trauma symptoms.
This study tests whether a single dose of psilocybin (a psychedelic compound) can help treat depression by looking at brain changes on MRI. It is designed for people with moderate-to-severe depression who have not responded well to other treatments.
This study tests whether psilocybin (a psychedelic medicine) combined with talk therapy can help reduce PTSD symptoms in people who have experienced intimate partner violence. If you join, you'll receive the treatment in a supportive setting and be followed to see if it helps.
This trial tests whether a single dose of psilocybin can help people with treatment-resistant depression by changing how they focus on themselves. It aims to understand how psilocybin affects brain activity and self-related thinking.
This study tests whether a combination of mindfulness training and a single dose of psilocybin can help reduce PTSD symptoms. It is for people with moderate-to-severe PTSD who are not on certain medications and do not have major health problems.
This trial tests whether a medicine called psilocybin (the active ingredient in 'magic mushrooms') combined with therapy can help treat depression. You would have a few sessions with a therapist and receive the medicine in a safe setting, which might improve your mood.
Hear when a new Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.