Clinical trials
Major Depressive Disorder clinical trials
Below are recruiting major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 502 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04685148RecruitingPhase 1/Phase 2
Study of mental health treatment during pregnancy
This trial studies a treatment aimed at improving maternal mental health during pregnancy. It focuses on people who have had depression around pregnancy before, and checks whether the approach is safe and helpful for them.
CopenhagenAges 18–45 - NCT05480150Recruiting
Study of brain and mood in people with depression or bipolar disorder
This study is following and assessing people with major depression or bipolar disorder to better understand the condition and how the brain relates to symptoms. It may help researchers develop more targeted support by comparing brain and health information over time.
Hangzhou, ZhejiangAges 16–65 - NCT05913960Recruiting
Theta-burst brain stimulation for major depression
This study tests whether an “accelerated intermittent theta-burst” brain stimulation treatment can improve major depressive disorder by affecting brain signaling pathways. You may be a candidate if you have moderate-to-severe depression and can safely undergo brain MRI.
Hangzhou, ZhejiangAges 12–45 - NCT05583747Recruiting
Brain stimulation therapy with guidance for treatment-resistant depression
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
Toronto, OntarioAges 18–65 - NCT05527509Recruiting
Study of risk and resilience in new RCMP cadets
This study follows people as they start RCMP Cadet Training to learn what factors affect “risk” and “resilience” (how well someone adapts under stress). It may help improve support for cadets during training.
Regina, SaskatchewanAges 19–57 - NCT07873060Recruiting
Brain stimulation for depression in teens
This study compares two types of non-invasive brain stimulation (using magnetic pulses) to see which works better for teenagers with depression. It aims to find a safe, effective treatment that may help improve mood without medication.
Jinan, ShandongAges 11–19 - NCT06054321Recruiting
Depression medication study for adults 19 to 65
This study tests a new way of choosing antidepressants for people with major depression. It's designed for adults aged 19–65 who have moderate to severe depression and are either starting a new antidepressant or have been off psychiatric meds for at least a month.
GwangjuAges 19–65 - NCT06417437RecruitingPhase 4
Brain-computer interface test for depression
This trial tests a non-invasive brain-computer interface (BCI) to help people with depression. It may be a good fit for teenagers and adults who are right-handed, Han Chinese, and have moderate to severe depression without other major health problems.
Shanghai, Shanghai MunicipalityAges 12 years+ - NCT07845604RecruitingPhase 2
Testing an anti-inflammatory drug with Lexapro for depression
This study tests whether an anti-inflammatory medication (adalimumab, also known as Humira) can help treat depression when added to Lexapro. It may help people whose depression is linked to higher levels of inflammation in the body.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07834684Recruiting
Singula health survey for routine primary care visits
This study tests a new survey during a regular doctor's visit to see if it helps improve care. If you join, you'll answer questions on your own device.
Brentwood, New YorkAges 18 years+ - NCT06467474Recruiting
Group Education Program for Depression
This trial tests a group education program (psychoeducation) for people with moderate to severe major depression. It’s designed to help you learn skills to manage your depression alongside medication.
São PauloAges 18–59 - NCT07810023Enrolling by invitation
Ketamine shot for suicidal distress in the emergency room
This study tests whether a single ketamine injection can quickly reduce suicidal thoughts in people waiting to be admitted to the psychiatric unit. Ketamine is a fast-acting medication that may help calm the mind during a crisis.
Evanston, IllinoisAges 18 years+ - NCT06542094Recruiting
Brain stimulation for severe depression that hasn't improved with other treatments
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
Chengdu, SichuanAges 18–65 - NCT05409794Recruiting
Testing blood lithium levels in people with depression and suicidality
This study checks how much lithium is naturally present in the blood and whether that relates to suicidal thoughts or attempts in people with a current major depressive episode. It may help researchers understand biological factors linked to suicide risk and improve future prevention.
MontpellierAges 18 years+ - NCT07783633Enrolling by invitation
Digital tools for mood disorders study
This study looks at whether using digital tools, like apps or online programs, can help people with mood disorders like depression or bipolar disorder. It aims to find markers that show who might benefit most from these tools.
Toronto, OntarioAges 16 years+ - NCT07779707Recruiting
Healthy groceries for people with depression and food needs
This study gives free, healthy groceries made to match your health needs and offers support to help improve your mood and reduce stress. It aims to see if getting nutritious food can help people with depression feel better.
Worcester, MassachusettsAges 18 years+ - NCT07775300RecruitingPhase 3
Study of an injectable drug for major depressive disorder
This study tests an investigational drug called brenipatide for major depressive disorder. It is given as a self-injection and is being compared to a placebo to see if it helps improve depression symptoms in people who are already on standard treatment.
Birmingham, AlabamaAges 18–75 - NCT06409325Recruiting
Magnetic Seizure vs. Electric Shock for Depression
This study compares two brain stimulation treatments—Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT)—to see which works better for severe depression. If you are on a stable antidepressant and haven't had recent brain stimulation, this trial may be an option for you.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07768397Recruiting
Comparing two brain-stimulation schedules for depression
This study tests two different schedules of a treatment called theta burst stimulation, which uses magnetic pulses to gently stimulate the brain. It aims to find out if the faster schedule works better than the standard one for people with major depression.
Ho Chi Minh CityAges 18–65 - NCT06005194Recruiting
Exercise therapy via telehealth for depression after brain injury
This study tests whether an exercise program delivered through video calls can help treat major depression in people who have had a traumatic brain injury. If you are at least one year past your injury and have symptoms of depression, you may be able to join.
Seattle, WashingtonAges 18–64 - NCT07757997Recruiting
Recovery and work after stress treatment
This study checks how people who completed a hospital program for stress-related issues are doing over time, focusing on their health and ability to work. It aims to understand the long-term effects of the treatment.
SüsAges 18–80 - NCT07758010Recruiting
Brain stimulation for treatment-resistant depression
This study tests a type of brain stimulation called cTBS (continuous theta burst stimulation) applied to a specific part of the brain (the precuneus) to see if it helps with treatment-resistant depression. It aims to provide a new option for people who haven't found relief from standard treatments.
Belmont, MassachusettsAges 18 years+ - NCT07749521Recruiting
Treating depressed parents of children with behavioural problems
This study tests a virtual group treatment to help parents with mild to moderate depression improve their own wellbeing and better support their child's emotional and behavioural health. If you are a parent with depression and have a child aged 6-11 who is struggling emotionally or behaviourally, this trial may be for you.
Toronto, OntarioAges 18 years+ - NCT07748091Recruiting
Brain wave and inflammation markers in shock therapy for depression
This study looks at brain wave patterns and markers of inflammation in people with depression that hasn't improved with other treatments and who are receiving electroconvulsive therapy (ECT, also known as shock therapy). The goal is to understand how these markers might relate to how well ECT works.
Istanbul, BakırköyAges 18–60
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Major Depressive Disorder trials by city
Studies with a site in or near these metro areas.
Major Depressive Disorder trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for major depressive disorder?
- Yes. Clin2 currently lists 502 recruiting major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.