Combination therapy for advanced HR+/HER2+ breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests a new combination of drugs for advanced breast cancer that is both hormone receptor-positive (HR+) and HER2-positive. The treatment combines fulvestaciclib (a CDK4/6 inhibitor) with anti-HER2 therapy and endocrine therapy, aiming to slow or stop cancer growth. It may be an option if you have not yet had treatment for advanced disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have advanced breast cancer that cannot be removed by surgery and has spread or come back.
- Your cancer is both HR+ and HER2+ (confirmed by biopsy).
- You have not had any prior treatment for advanced breast cancer (like endocrine therapy, chemotherapy, or anti-HER2 therapy).
- If you had prior adjuvant therapy, you must have had a break of at least 12 months (for endocrine) or 6 months (for anti-HER2) before joining.
- You are generally well enough (ECOG score 0-1) and have adequate organ function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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