Eye cell therapy for corneal swelling
Part of Eyes & vision, Genetic & congenital clinical trials.
This trial tests an investigational cell therapy called EO2002 for people with corneal edema (swelling of the clear front part of the eye) caused by endothelial dysfunction, which can happen with Fuchs dystrophy or after cataract surgery. The treatment aims to restore the inner layer of the cornea to reduce swelling and improve vision.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have corneal swelling in the center of your eye that is causing vision loss.
- Your vision in the study eye is between 20/40 and 20/400 (measured on an eye chart).
- Your cornea is thicker than normal (≥ 600 micrometers), or you have other signs of swelling.
- You are eligible for a corneal transplant or endothelial keratoplasty (a partial-thickness corneal transplant) as part of standard care.
- You do not have other significant eye diseases like herpes infection, severe dry eye, corneal scars, keratoconus, or glaucoma surgery in the past.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 study tests whether EO2002 eye drops are safe and well tolerated in people with painful corneal swelling caused by the cornea’s inner lining not working well. It focuses on safety first, but your eye symptoms and vision may be monitored to see how you respond.
This trial studies a treatment for people with Fuchs’ dystrophy that affects the clear layer at the back of the cornea. It may help improve how clear your vision is after the cornea can no longer pump fluid out properly.
This Phase 1 study tests how safe and tolerable an investigational treatment (EO2002) is in adults having cataract surgery. It also looks at whether the treatment can be given without causing harmful effects in people with reduced cornea cell counts.
This trial tests a new corneal implant to treat corneal swelling caused by Fuchs' dystrophy or after cataract surgery. It aims to improve vision and reduce the need for a full corneal transplant.
This Phase 1 trial tests a new, lab-made tissue transplant to improve corneal clarity in people with certain types of corneal endothelium failure (eye swelling) caused by specific conditions. The main goal is to check safety and see if vision and corneal health improve.
This Phase 3 trial compares outcomes from two cornea transplant procedures in people with FECD, a disease that makes the cornea swell and affect vision. It may help you and others by identifying which approach best supports clear vision and stable corneal thickness after surgery.
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