Switching to oral weight-loss pills to prevent weight regain after stopping GLP-1 injections
Treatments studied
Part of Hormones & metabolism clinical trials.
This study tests whether switching to an oral weight-loss medication can help you keep off the weight you lost after stopping a GLP-1 injection like semaglutide or tirzepatide. You might qualify if you live in Massachusetts, are between 18 and 80, have a BMI of 30 or higher, lost at least 10% of your body weight on these injections, and are willing to be randomly assigned to a new treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 80 years old
- You live in Massachusetts
- Your BMI was 30 or higher before starting weight-loss injections
- You are currently using or have recently (within 8 weeks) used a GLP-1 injection like semaglutide or tirzepatide
- You have lost at least 10% of your starting body weight with these injections
- You do not have type 2 diabetes, a history of pancreatitis, or certain heart or thyroid conditions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a GLP-1 medication (a type of drug that helps with weight loss) can safely and effectively help young adults with type 1 diabetes who also have obesity. It aims to see if adding this treatment to insulin can improve weight and blood sugar control.
This study tests an oral medicine (semaglutide) to see if it helps adults with excess weight lose weight. It might offer an easier, pill-based treatment option for weight management.
This study tracks how semaglutide (an injectable medication that reduces appetite) helps adults lose weight in everyday life. Researchers want to understand how well it works and how safe it is for people starting the treatment.
This study tests a nasal spray containing semaglutide (a GLP-1 receptor agonist) to see if it helps adults who are overweight or obese lose weight. It may be an option if you have a BMI between 27 and 35 and have not used other weight loss medications recently.
This study looks at different ways to help you keep weight off after you stop taking a weight loss medication. You will work with your primary care team to learn healthy habits and get support without the drug.
This early-stage study looks at how genetic factors may change how people respond to a GLP-1 medicine (semaglutide). The goal is to learn who may benefit most and why, so future treatments can be better matched.
Hear when a new Obesity trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.