Gene therapy for MASH (fatty liver disease)
Part of Digestive system, Hormones & metabolism clinical trials.
This trial tests an experimental gene therapy (VV-14303) given as a single injection into the muscle to treat MASH, a common type of fatty liver disease with inflammation. The study will check if the treatment is safe and helps improve liver health.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of MASH (fatty liver with inflammation) from a liver biopsy.
- You are 18 to 75 years old.
- Your body mass index (BMI) is between 25 and 40.
- You have at least two of these: obesity (BMI 25+), high blood pressure, abnormal cholesterol or triglycerides, or type 2 diabetes.
- Male participants must use effective contraception for 12 months after the injection; female participants cannot be capable of becoming pregnant.
- You cannot have other serious liver diseases, type 1 diabetes, or poorly controlled type 2 diabetes.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests a gene-silencing treatment to improve chronic liver disease called MASH, especially in people with certain genetic risk. You may be eligible if you have MASH with moderate-to-advanced scarring and specific test results, and if other liver causes and recent substance/alcohol issues don’t apply.
This trial tests two new injections (HRS-4729 and HRS-9531) for people with MASH, a type of fatty liver disease. The study aims to see if these drugs can help reduce liver fat and improve liver health.
This trial tests a new medication called UBT251 for people with MASH, a type of liver disease linked to weight and metabolism. It aims to see if the medicine can reduce liver damage and scarring.
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This trial tests an investigational drug called IBI362 for people with MASH, a type of fatty liver disease that has caused liver scarring (stage F2 or F3). The study aims to see if the drug can improve the liver's health.
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