Testing a weight-loss injection for knee arthritis pain
Part of Bones, joints & muscles, Hormones & metabolism clinical trials.
This study tests whether an experimental weight-loss injection can reduce knee pain in people who are obese and have knee osteoarthritis. It may help if you have been unable to lose weight through diet and exercise and have moderate knee pain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a body mass index (BMI) of 28 or higher.
- You must have knee osteoarthritis with moderate changes seen on X-ray (grade 2 or 3).
- Your knee pain should have lasted more than 12 weeks, and you should have felt it on more than 15 days in the last month.
- Your knee pain score should be between 4 and 9 on a 0-10 scale.
- You must have tried diet and exercise to lose weight but not succeeded.
- You must not have had knee replacement surgery or certain knee procedures recently.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
This study tests an experimental medicine called KBP-336 for people with both obesity and knee osteoarthritis who still have significant knee pain despite standard treatments. It aims to see if KBP-336 can reduce pain and improve function.
This study tests a new injection (MWN117) in healthy people and in people with obesity. It aims to see if the drug is safe and how the body handles it, which may eventually help with weight management.
This study uses fat tissue from your own body, processed with a special device, and injects it into the knee to help reduce pain and improve function in knee osteoarthritis. It's a minimally invasive treatment that might be an option for people who have not found relief from other treatments.
This study tests an investigational medication called ribupatide, given as an injection, to see if it helps reduce knee pain and improve function in people who have both obesity and knee osteoarthritis. It may also help with weight loss.
Hear when a new Knee Osteoarthritis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.