Clin2
NCT07738068Possibly a fitNot yet recruiting

Progesterone support during natural cycles for unexplained infertility

InfertilityFemale InfertilitySubfertilityInfertility PrimaryInfertility SecondarySubfertility, Female

Part of Women’s health & pregnancy clinical trials.

This trial tests whether using a natural hormone (progesterone) as vaginal suppositories during the second half of your cycle can improve your chances of getting pregnant while you wait and try naturally. It is for couples with unexplained infertility and a good chance of conceiving on their own.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
640 people
Ages
18 years to 43 years
Study type
Interventional

Who can take part

  • You have been trying to conceive for at least one year and have been diagnosed with unexplained infertility.
  • You have a regular menstrual cycle (21–35 days) and a partner's sperm count of at least 10 million per ml.
  • Your doctor has calculated that your chance of natural conception within the next year is 30% or higher.
  • You are willing to wait at least six more months without active fertility treatment before trying other options.
  • You are 18 or older, have a BMI under 45, and are not allergic to peanuts or soya.
  • You do not have untreated uterine conditions (like polyps or fibroids) or a diagnosis of endometriosis.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05899010Recruiting· Phase 3
Micronized progesterone for frozen embryo transfers

This Phase 3 study tests whether adding micronized progesterone during frozen embryo transfer cycles helps support embryo implantation and pregnancy. You may benefit if your care team is already preparing the uterus with hormone therapy for a blastocyst transfer.

Barcelona
NCT07508657Recruiting· Phase 4
Progesterone after letrozole for intrauterine insemination

This trial tests whether taking progesterone after a type of fertility treatment called IUI can improve success rates. The study focuses on people who are using a drug called letrozole to stimulate the ovaries.

Copenhagen
NCT02357654Recruiting· Phase 4
Hormone treatment to support the uterine lining in IVF cycles

This trial tests whether a hormone called GnRH can help support the lining of the uterus after IVF, ICSI, or frozen embryo (FET) embryo transfer. It may be offered around the time of embryo transfer to improve the chances of a successful implantation.

Hasbrouck Heights, New Jersey
NCT03859921Recruiting· Phase 3
Dydrogesterone pill support during natural-cycle embryo transfer

This Phase 3 study tests whether taking an oral progesterone-like medicine (dydrogesterone) during the “luteal phase” after a natural-cycle frozen embryo transfer can improve support for implantation. It may help couples who are using their own embryos in a natural (hormone-sparing) cycle after thawing.

Hong Kong, Hong Kong
NCT07340827Recruiting· Phase 3
Comparing two fertility drugs in Japanese women with hormone deficiency

This study tests if a combination of two hormone drugs (follitropin alfa/lutropin alfa) works as well as another drug (hMG) for Japanese women with low LH and FSH levels who are doing in vitro fertilization (IVF). The goal is to help them produce eggs for pregnancy.

Akita, Akita
NCT07461909Recruiting
Comparing Two Types of Vaginal Progesterone for Frozen Embryo Transfer

This study compares two forms of vaginal progesterone used to prepare the uterus for a frozen embryo transfer (FET). It may be a good option if you are already prescribed one of these progesterone regimens and are planning a single embryo transfer.

Lisbon

Hear when a new Infertility trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.