Cyclophosphamide and pembrolizumab for advanced melanoma
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests a combination of daily low-dose cyclophosphamide (a chemotherapy pill) and pembrolizumab (an immunotherapy) in people with advanced melanoma that has stopped responding to prior immunotherapy. The goal is to see if this combination can help shrink tumors or slow the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stage 3 or stage 4 melanoma that cannot be removed by surgery and is not in the eye or uvea.
- You have tried a PD-1 or PD-L1 immunotherapy before, and your cancer got worse while on it.
- You are at least 18 years old and able to care for yourself (ECOG score 0-2).
- Your overall health—including kidney, liver, and blood counts—is adequate based on standard tests.
- If you have had brain metastases, they must be treated and stable for at least 28 days, and you must be on a low stable dose of steroids.
- You must agree to use effective birth control if you or your partner could become pregnant, and not donate sperm during the study and for a period after.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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