Long-term treatment for healed acid reflux damage
Part of Digestive system clinical trials.
This study tests a new medicine to keep acid reflux from damaging the esophagus again after it has healed. It may help prevent symptoms like heartburn from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 19 and 75 years old.
- You have been diagnosed with erosive esophagitis (acid reflux that has damaged the esophagus) and it has healed after standard treatment.
- You can attend study visits and complete questionnaires.
- You do not have serious other conditions like bleeding ulcers, cancer, or certain digestive diseases.
- You are willing to use birth control if you are of childbearing age.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new medication (JP-1366) to see if it helps prevent acid reflux damage from coming back. You may join if you have had erosive esophagitis that healed after treatment, and you are currently doing well without other serious conditions.
This study tests a new topical treatment for people with chronic heartburn and acid regurgitation who don't have erosions (damage) in their esophagus. The treatment is applied directly to the affected area and may help relieve symptoms without taking daily pills.
This study tests an investigational medication called JP-1366 for people with non-erosive GERD, a condition where acid reflux causes heartburn and regurgitation but no visible damage to the esophagus. The goal is to see if this new treatment can safely reduce symptoms better than a placebo.
This trial tests vonaprazan (two doses) against esomeprazole to see which better heals moderate-to-severe reflux esophagitis (a damaged esophagus from acid reflux) in 8 weeks. You may qualify if you have had heartburn or regurgitation for at least a month and your doctor found grade B, C, or D damage on an endoscopy.
This trial tests a new way to treat GERD (chronic acid reflux) using a tiny camera and a device that delivers a gentle heat treatment (argon plasma coagulation) to the area where the stomach meets the esophagus. It's compared to a 'sham' procedure (you won't know which you get) to see if it stops acid from backing up better than medicine alone.
This trial compares two medicines—vonoprazan and esomeprazole—to see which is better at healing acid damage to the esophagus (erosive esophagitis). If you have had heartburn and an endoscopy confirmed inflammation, you may be eligible for this study.
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