Comparing three medicines for severe acid reflux healing
Treatments studied
Part of Digestive system clinical trials.
This trial tests vonaprazan (two doses) against esomeprazole to see which better heals moderate-to-severe reflux esophagitis (a damaged esophagus from acid reflux) in 8 weeks. You may qualify if you have had heartburn or regurgitation for at least a month and your doctor found grade B, C, or D damage on an endoscopy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have moderate-to-severe esophagitis confirmed by an endoscopy (grade B, C, or D).
- You have had acid reflux symptoms like heartburn or regurgitation for at least 4 weeks.
- You have not taken vonaprazan or esomeprazole in the last 4 weeks.
- You have not had surgery or radiation on your esophagus.
- You are not pregnant, breastfeeding, or on NSAIDs, steroids, or blood thinners that could affect healing.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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