Study of GPX4 protein in Crohn's disease after bowel surgery
This study looks at a protein called GPX4 in the tissue of people with Crohn's disease who had bowel surgery. It compares two ways of reconnecting the intestine (Kono-S versus conventional) to see if there's a difference in GPX4 levels, which might help explain why one method works better for some people.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have been diagnosed with Crohn's disease.
- You have had surgery to remove part of your small bowel or ileum and reconnect the two ends (an anastomosis).
- The type of anastomosis (conventional or Kono-S) is known and recorded.
- The hospital can access preserved tissue from your removed bowel specimen that includes the anastomosis area.
- You have an additional tissue sample from before the surgery or from a follow-up scope within 24 months after surgery.
- You have follow-up endoscopy results (Rutgeerts score) if available.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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