GPX4 protein in bowel tissue after two types of Crohn's surgery
Part of Digestive system, Immune system & allergy clinical trials.
This study looks at a protein called GPX4 in the bowel tissue of people with Crohn's disease who had surgery. It compares two ways of reconnecting the bowel to see if one is better for long-term healing, which might help future patients choose the best surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have Crohn's disease and had surgery to remove a section of your bowel, then the healthy ends were reconnected.
- The exact method of reconnection (known as Kono-S or conventional) is recorded.
- Tissue samples from the surgery (or a prior or follow-up endoscopy) are available for testing.
- You have follow-up endoscopy information (called a Rutgeerts score) that shows the condition of the connection area.
- You do not have serious complications at the time of surgery that could affect the results.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how an environmental factor may be linked to Crohn’s disease, especially around the time you need certain bowel surgery. Your experience may help researchers understand risk and how it relates to your gut health.
This trial tests if checking a stool marker (fecal calprotectin) early after surgery can guide treatment with ustekinumab to prevent Crohn's disease from coming back. It's for people who had certain bowel surgery and have at least one risk factor for recurrence.
This study compares two ways to choose biologic (targeted) medicines after Crohn’s surgery to help stop Crohn’s from coming back in the bowel. It may help you avoid or delay repeat inflammation by adjusting treatment based on endoscopy findings.
This trial compares two ways of reconnecting the bowel after surgery in people with Crohn’s disease that affects the small intestine and/or colon. It aims to see which reconnection method works better after the initial surgery, even if you’re on Crohn’s medicines before the operation.
This study looks at what happens to people with Crohn's disease after they have surgery to remove a diseased part of their intestine. The goal is to find patterns or signs that might help predict whether the disease will come back, which could help doctors plan better follow-up care.
This study looks at how certain immune cells relate to Crohn's disease coming back after bowel surgery. The goal is to better understand why some patients have a recurrence, which could help improve future treatments.
Hear when a new Chrohn's Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.