Clin2
NCT07779811Possibly a fitNot yet recruiting

Metformin cream versus triple cream for skin darkening

Epidermal MelasmaFacial Hyperpigmentation

Part of Skin clinical trials.

This study compares a cream containing metformin to a triple combination cream for treating melasma, which causes brown patches on the face. The goal is to see which treatment is more effective in lightening these patches.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
104 people
Ages
18 years to 50 years
Study type
Interventional

Who can take part

  • You are between 18 and 50 years old.
  • Your skin darkening is the epidermal type (confirmed by a Wood's lamp test).
  • You have not used any melasma treatment in the past month.
  • You have not had procedures like dermabrasion, laser, or chemical peels in the past 3 months.
  • You are not pregnant and do not have other skin conditions like acne or rosacea.
  • You can provide written consent to participate.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07071363Recruiting
Serum vs hydroquinone for melasma treatment

This trial compares a new cosmetic serum to a standard treatment (4% hydroquinone) for facial melasma over 84 days. It may help if you have mild to moderate melasma and are looking for a gentler alternative.

Port Louis, Phoenix
NCT07485777Not yet recruiting
Metformin cream vs. standard melasma treatment in women

This study compares a metformin cream to a standard treatment (Kligman's regimen) for reducing melasma, a common skin condition causing dark patches on the face. It aims to find which treatment is more effective for women with this condition.

Rawalpindi, Punjab Province
NCT07495748Not yet recruiting
Comparing two creams for facial melasma

This study compares two creams — metformin and tranexamic acid — to see which works better for melasma (dark patches on the face). If you qualify, you'll use one of the creams and your progress will be checked over time.

Rawalpindi, Punjab Province
NCT06780644Not yet recruiting
Comparing two combination creams for treating melasma

This study compares two different combination creams for treating melasma, a common skin condition causing dark patches on the face. One cream includes a mild steroid and the other has a different steroid, both with the same lightening ingredients. The goal is to see which works better and is safer for your skin.

Central Jakarta, DKI Jakarta
NCT06942390Not yet recruiting· Phase 2
Comparing two creams for treating melasma in women

This study compares two different creams applied to the skin — metformin and ketotifen — to see which works better for treating melasma (dark patches on the face). If you are a woman with melasma, you may be eligible to join and receive one of these creams.

NCT07696806Enrolling by invitation· Phase 4
Needle-assisted treatment for melasma using common skin medications

This trial tests a microneedling technique combined with three topical medications (metformin, tranexamic acid, and a modified Kligman's formula) to treat melasma, a common skin condition causing dark patches. The goal is to see if this approach safely and effectively reduces melasma in eligible women.

Tanta

Hear when a new Epidermal Melasma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.