Liver transplant for stable colorectal cancer spread to the liver
Part of Cancer, Digestive system clinical trials.
This trial tests whether a liver transplant can help people with colorectal cancer that has spread to the liver, when the cancer is stable on chemotherapy and can't be treated with local methods. The goal is to offer a potential cure or longer-term control for those who qualify.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 65 years old.
- Your colorectal cancer has spread to the liver, and the liver tumors cannot be removed with surgery or destroyed with other local treatments (like ablation) because there wouldn't be enough healthy liver left.
- Your liver tumors have been stable for at least 6 months while you're on chemotherapy. You've had no more than 2 different types of chemotherapy.
- If your colorectal cancer was discovered after the liver spread (metachronous), the original tumor in the colon/rectum must have been fully removed with clear margins. If it was discovered at the same time (synchronous), the primary tumor must be potentially curable with surgery.
- You must not have cancer spread to the lining of your abdomen (peritoneum), and you must not have certain genetic mutations (BRAF V600E or MSI-H/dMMR) in your tumor.
- You must be healthy enough for a liver transplant and follow other study rules.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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