Prostate removal without a prior biopsy for high-risk cancer
Part of Cancer, Kidney & urinary clinical trials.
This study tests removing the entire prostate gland (radical prostatectomy) without doing a biopsy first. It is for men with a very high PSA and strong imaging signs of cancer that has not spread, so they can start treatment sooner.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your PSA test result must be 20 or higher.
- A digital rectal exam must have found something suspicious (like a lump or hardness).
- An MRI must show a prostate area that is likely cancer (reported as PI-RADS 4 or 5).
- A PSMA PET scan must show the cancer is only in the prostate, not spread to other parts of the body.
- You cannot have had a previous prostate biopsy that confirmed cancer.
- You must be healthy enough for surgery (prostate removal) and general anesthesia, and agree to the study procedures.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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