Prostacyclin as an extra blood thinner for children on ECMO
This study tests whether adding a medicine called prostacyclin (which helps keep blood from clotting) to the standard blood thinner can help children on ECMO—a machine that takes over heart and lung function—have fewer clotting problems and bleeding issues.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 17.5 years old or younger when the ECMO machine is started.
- You must be at least 37 weeks corrected age (for babies born early).
- You must be in a children's intensive care unit (PICU, CICU, or NI/ICU) and need ECMO support.
- You must already be receiving a standard blood thinner (either heparin or bivalirudin).
- Your parent or legal guardian must agree to the study in writing.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies a safe, backup ECMO machine for people with very weak hearts or complex blockages who need high-risk stenting. It helps keep your blood pumping if your heart struggles during the procedure.
This study looks at whether a blood test called D-dimer can help predict bleeding in patients on ECMO, a machine that helps the heart or lungs. It aims to improve safety by monitoring this marker.
This trial tests a way to manage blood clotting in patients on ECMO (a machine that helps breathe for very sick patients). It uses a drug called Nafamostat with a lower dose of standard blood thinners, which may reduce bleeding risks.
This trial tests if bivalirudin is a safe and effective blood thinner for people on ECMO, a machine that helps your heart and lungs. You may be eligible if you need this therapy and have no past reactions to similar medicines.
This Phase 2 trial compares two blood-thinning medicines—bivalirudin and heparin—in people on ECMO (a machine that supports breathing and/or circulation). It aims to see which medicine works better and is safer while you are connected to the ECMO circuit.
This study tests whether using lower doses of two blood thinners, argatroban and enoxaparin, is safe and works well for people on ECMO. ECMO is a machine that helps your heart and lungs work when they are very sick, and this trial aims to reduce bleeding risks while keeping blood from clotting.
Hear when a new ECMO trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.