Bivalirudin vs heparin for blood thinning during ECMO
Treatments studied
Part of Heart & circulation clinical trials.
This Phase 2 trial compares two blood-thinning medicines—bivalirudin and heparin—in people on ECMO (a machine that supports breathing and/or circulation). It aims to see which medicine works better and is safer while you are connected to the ECMO circuit.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are currently receiving ECMO (the life-support machine)
- You are 18 years or older
- The study team can randomize you within 4 hours after ECMO is started
- You are not a “post-cardiotomy” ECMO patient (ECMO started right after heart surgery)
- You can take either heparin or bivalirudin safely at the time of enrollment (no major active bleeding or known allergy/contraindication)
- You are not expected to be taken off ECMO within the next day after the tubes are placed
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if bivalirudin is a safe and effective blood thinner for people on ECMO, a machine that helps your heart and lungs. You may be eligible if you need this therapy and have no past reactions to similar medicines.
This trial studies whether people on a breathing machine called VV-ECMO can be managed without routine blood thinners, to reduce bleeding risk. It is meant for adults with severe lung failure (ARDS) and checks that it is safe for you to avoid anticoagulation.
This trial tests a medicine called nafamostat mesilate to prevent blood clots in patients who need ECMO (a machine that helps your heart and lungs) after heart surgery. It may offer a safer way to thin the blood compared to standard treatments.
This study looks at how platelets (the cells that help clot blood) behave in patients on a lung-support machine called ECMO. By taking blood samples, researchers hope to better understand clotting issues that can occur during ECMO support.
This trial compares three different blood thinners (heparin, argatroban, and enoxaparin) used during ECMO support. It aims to find the safest and most effective way to prevent blood clots while on ECMO.
This study tests whether using lower doses of two blood thinners, argatroban and enoxaparin, is safe and works well for people on ECMO. ECMO is a machine that helps your heart and lungs work when they are very sick, and this trial aims to reduce bleeding risks while keeping blood from clotting.
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