Molecular markers and outcomes in early-stage endometrial cancer
Part of Cancer, Women’s health & pregnancy clinical trials.
This study looks at women with certain high-risk types of endometrial cancer that have not spread into the muscle wall of the uterus. It aims to understand how these cancers behave and whether lymph node testing is needed, which could help guide treatment decisions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- 18 years or older
- Had surgery for endometrial cancer that has not invaded the uterine muscle
- Have a tumor type called p53-abnormal, ER-negative, or high-grade NSMP
- Had lymph node sampling during surgery (sentinel node biopsy or lymphadenectomy)
- No DNA mismatch repair deficiency or POLE-ultramutated tumor
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two ways of removing lymph nodes during surgery for a high-risk type of uterine (endometrial) cancer with a p53 gene mutation. You would be randomly assigned to either removing only the sentinel (first few) lymph nodes or removing many lymph nodes, to see if the less invasive approach is just as good.
This study looks at combining genetic testing with surgical exams to better understand endometrial cancer. It may help doctors see which treatments could work best for you.
This trial looks at better ways to predict how aggressive your endometrial cancer is before surgery, so doctors can decide if they need to check your lymph nodes. It may help tailor your treatment to avoid unnecessary procedures.
This trial compares chemotherapy alone versus chemotherapy plus radiation therapy for people with endometrial cancer that has a p53 mutation. The goal is to see which approach better prevents the cancer from coming back after surgery.
This trial tests a tailored approach to preserve fertility in women with early-stage endometrial cancer, using medications like hormones and immunotherapy based on the tumor's molecular subtype. It aims to avoid hysterectomy and keep the uterus intact.
This study tests whether immunotherapy, a treatment that helps your immune system attack cancer cells, is effective against advanced or recurrent endometrial cancer. It aims to see how well the treatment works based on specific genetic markers in your tumor.
Hear when a new Endometrial Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.