Comparing medical care with or without a procedure for moderate carotid narrowing
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This study compares two approaches for people who have recently had a stroke or mini-stroke caused by a moderately narrowed carotid artery in the neck. Half will get the best medical treatment alone (like clot-preventing medicines and risk-factor management), and the other half will get the same medical treatment plus a procedure to open the narrowed artery (either surgery or a stent). The goal is to see which approach better prevents future strokes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years of age or older.
- You have had a recent stroke, a mini-stroke (TIA), or a temporary or permanent loss of vision in one eye within the last 14 days, caused by a narrowed carotid artery in your neck.
- The narrowing in your carotid artery is between 50% and 69%, OR it is less than 50% but has certain high-risk features (such as bleeding inside the plaque or an irregular surface).
- You are able to have either of the two standard procedures to open the narrowed artery (surgery or stenting).
- Your general health is good enough that you are expected to live at least 5 years (no severe kidney, heart, or lung disease, or active cancer).
- You do not have atrial fibrillation (an irregular heartbeat) or a history of it, and you are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether surgery to remove plaque from a narrowed carotid artery (the main artery in the neck that supplies blood to the brain) helps people who have had symptoms like a stroke or transient ischemic attack (TIA). The goal is to see if this surgery reduces the risk of future strokes.
This trial compares the best timing for surgery or stenting to open a narrowed carotid artery after a minor stroke. The goal is to see if doing the procedure sooner or later reduces the chance of another stroke.
This trial tests a stent procedure to open a severely blocked carotid artery in people who have not had a stroke or mini-stroke from that blockage recently. It aims to see if the procedure is safe and effective for preventing future strokes.
This trial compares two procedures—surgery to remove plaque from a carotid artery or placing a stent to widen the artery—to see which is better for people who recently had warning signs or a small stroke due to a severe blockage. The goal is to find the safest and most effective way to prevent future strokes.
This trial compares two procedures to open a blocked carotid artery in people who recently had a stroke. One option is surgery (carotid endarterectomy) to remove the blockage, the other is stenting (placing a small mesh tube to hold the artery open). The goal is to see which works better for patients still having some stroke symptoms.
This trial tests if a carotid artery stent plus medication is better than medication alone at preventing another stroke in people who recently had a stroke or eye blockage caused by a non-narrowing but risky carotid plaque.
Hear when a new Carotid Stenosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.