Comparing two IV antibiotics for serious urinary infections
Treatments studied
Part of Infections, Kidney & urinary clinical trials.
This trial tests a new antibiotic combo (ertapenem-zidebactam) against an existing one (ceftazidime-avibactam) for serious urinary tract or kidney infections in hospitalized patients. It aims to see if the new drug is as effective and safe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older and able to give written consent.
- You must be hospitalized for a complicated urinary tract infection or acute pyelonephritis (kidney infection).
- You need to have at least two symptoms like fever, nausea/vomiting, painful or frequent urination, or lower belly pain.
- You must have at least one complicating factor, such as a urinary catheter, urogenital abnormality, obstruction, or kidney problems.
- You must have evidence of pyuria (pus in urine) within 48 hours before the trial starts.
- You cannot have taken certain antibiotics within 72 hours before randomization, unless they failed or the bacteria are resistant.
- You must agree to use birth control if you are of childbearing potential.
- You cannot have severe kidney impairment (creatinine clearance <30 mL/min), be on dialysis, or have a history of seizures or serious allergies to β-lactam antibiotics.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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