Single-dose radiation for small breast cancers without surgery
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests whether a single, high-dose radiation treatment can safely replace surgery for very small, early breast cancers. If successful, it could offer an option for people who can't or don't want to have lumpectomy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your breast cancer must be a common type called invasive ductal carcinoma (or a very similar, low-risk type), and you must not have had a surgical biopsy or lumpectomy before.
- The tumor must be small (2 cm or less), be at least 5 mm away from the skin and chest wall, and not have spread to lymph nodes or other parts of the body.
- Your cancer must be estrogen receptor (ER) positive and HER2 negative, and have a low to moderate grade (1 or 2).
- You must be 65 or older, or be 50–64 and unable or unwilling to have surgery. Only 10 people in the younger group can join.
- You must be willing to take hormone-blocking therapy (endocrine therapy) for at least 5 years.
- You must be able to have MRI and PET/CT scans, and not have other serious medical conditions or a history of certain genetic mutations (like BRCA1/2).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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