Comparing two antidepressants to prevent migraines
Treatments studied
Part of Brain & nervous system clinical trials.
This study compares two common medicines, nortriptyline and amitriptyline, to see which works better at preventing migraines. Both are antidepressants that are often used to stop migraines before they start.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with migraines (with or without aura) for at least 12 months, and they started before age 50.
- You have 4 to 14 migraine days per month, but fewer than 15 headache days per month.
- You are able to keep a daily headache diary for 4 weeks before starting the study.
- You have not had a bad reaction or failed treatment with nortriptyline or amitriptyline in the past.
- You are not currently taking other migraine-prevention or interacting medicines that cannot be safely stopped.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a computer algorithm can help pick the best migraine prevention medicine for you. You'll try one of several common preventives and track your headaches.
This trial compares two different first-time preventive treatments for migraine in a primary care setting. If you qualify, you'll receive one of the study medications, and the research team will track how well it reduces your migraine days.
This study compares three common migraine prevention medications to see which works best. You might be able to join if you have migraines at least 4 days a month and haven't taken these specific drugs before.
This trial compares two medicines taken daily to prevent migraine headaches, with the goal of reducing how often they happen.
This study tests an investigational medication called NB001 for treating migraine attacks as they happen. If you have frequent migraines, this treatment might help reduce the severity or shorten the duration of your attacks.
This study looks at how well the combination of two migraine medicines (sumatriptan and naproxen) works in real life. If you already take this combination, participating could help doctors learn more about its effectiveness.
Hear when a new Migraine trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.