Clin2
NCT07870798Possibly a fitNot yet recruiting

Radiation plus immunotherapy and chemo before stomach cancer surgery

Gastric or Gastroesophageal Junction Adenocarcinoma

Treatments studied

This trial tests whether adding a targeted radiation treatment during surgery to the usual combination of immunotherapy and chemotherapy helps people with advanced stomach cancer before they have surgery to remove the tumor. The goal is to see if this extra treatment can improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
68 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are between 18 and 75 years old.
  • You have been diagnosed with stomach cancer or cancer where the stomach meets the food pipe (gastroesophageal junction), and it has not spread to other organs.
  • You have not had any prior treatment for this cancer, such as surgery, radiation, or chemotherapy.
  • Overall, you are in reasonably good health, with a performance status score of 0 or 1.
  • Your kidneys, liver, blood counts, and thyroid are functioning normally.
  • You are not pregnant or breastfeeding and agree to use effective contraception if applicable.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07674342Not yet recruiting
Comparing chemo-immunotherapy with or without radiation before surgery for stomach cancer

This trial tests whether adding a short course of radiation to a combination of chemotherapy and an immunotherapy drug (called a PD-1 inhibitor) before surgery helps shrink tumors and improve outcomes for people with upper stomach or gastroesophageal junction cancer.

Wuhan, Hubei
NCT06461910Recruiting· Phase 2
Immunotherapy, thymalfasin, and chemo before surgery for stomach cancer

This trial is testing a combination of three medicines—an immunotherapy (anti-PD-1), an immune booster (thymalfasin), and a chemotherapy regimen (SOX)—given before surgery to shrink stage III stomach or gastroesophageal junction cancer and improve outcomes.

Nanjing, Jiangsu
NCT06766578Recruiting· Phase 2
Low-dose radiation plus immunotherapy and chemo before gastric cancer surgery

This trial tests a new combination of low-dose radiation, an immunotherapy drug (tirelizumab), and chemotherapy (SOX) given before surgery for locally advanced gastric or gastroesophageal junction cancer. The goal is to see if this approach can shrink tumors more effectively.

Jinan, Shandong
NCT07859410Not yet recruiting
Immunotherapy plus chemoradiation before surgery for stomach cancer

This trial tests whether adding an immunotherapy drug called sintilimab to chemotherapy and radiation before surgery can help shrink tumors and improve outcomes for people with gastroesophageal junction cancer. It is designed for patients who have not had previous treatment for this cancer.

Hefei, Anhui
NCT07828873Not yet recruiting· Phase 2
Immunotherapy and chemotherapy before surgery for stomach cancer

This trial tests a combination of immunotherapy (QL1706) and chemotherapy before surgery for people with early-stage stomach cancer. The goal is to see if this approach shrinks the tumor and improves surgical outcomes.

Zhengzhou, Henan
NCT07018570Recruiting· Phase 2
Chemo, immunotherapy, and radiation for stomach cancer before surgery

This trial tests a combination of chemotherapy (FLOT), an immunotherapy drug (pembrolizumab), and short-course radiation before surgery for gastroesophageal junction cancer. The goal is to see if this approach improves outcomes.

Kashiwa, Chiba

Hear when a new Gastric or Gastroesophageal Junction Adenocarcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.