Clinical trials
Alcohol; Harmful Use clinical trials
Below are recruiting alcohol; harmful use clinical trials, each written for real people, not researchers. We’re tracking 20 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04351958Enrolling by invitation
AR videogame to prevent alcohol use in teens
This trial tests whether an augmented-reality (AR) videogame can help teens avoid drinking and reduce harm from alcohol. If you’re 16–18 and in high school, you may be asked to play the AR game during short sessions to see how well it works.
New Haven, ConnecticutAges 16–18 - NCT04957628Recruiting
Tailored interventions for people in hospital medical wards
This study tests whether personalized (tailored) interventions can help patients during their hospital stay in medical wards. You may be invited to participate if you can understand the study information and your stay is for a medical issue, not a major injury or planned surgery.
OsloAges 18 years+ - NCT04164940Recruiting
Tracking how hospital care affects alcohol risk in older adults
This study looks at how adults aged 21+ change over time after being admitted to the hospital for alcohol-related problems. It may help researchers understand which hospital approaches work best for reducing future alcohol-related harm—especially for people who have not had alcohol or drug use disorders before.
StavangerAges 21 years+ - NCT06286774Recruiting
Sleep and alcohol treatment study
This study tests whether improving sleep through cognitive behavioral therapy (CBT-I) can help reduce heavy drinking in people with both alcohol use disorder and insomnia. It might be a good fit if you have trouble sleeping and drink heavily.
Columbia, MissouriAges 18–49 - NCT06702007RecruitingPhase 3
E-help for reducing alcohol harm
This study tests a program that helps reduce harm from drinking for people in Housing First. It uses electronic tools and support to help you cut back safely.
Seattle, WashingtonAges 21 years+ - NCT07125534Recruiting
Alcohol and social interaction brain study
This study looks at how drinking alcohol affects brain activity during social interactions. You will be asked to visit the lab, consume a measured amount of alcohol, and have your brain activity recorded while talking or interacting with others. It aims to help understand social brain function.
Champaign, IllinoisAges 21–30 - NCT05781009RecruitingPhase 2
Pregnenolone treatment for alcohol use disorder
This Phase 2 study tests pregnenolone to help reduce or improve alcohol use disorder symptoms. It looks for adults who drink regularly and meet diagnostic criteria for moderate to severe alcohol use disorder, while excluding people with certain other substance use, medicines, or serious mental/medical conditions.
New Haven, ConnecticutAges 18–70 - NCT05855031Recruiting
Liver care support for people getting alcohol-use treatment
This trial looks at liver-focused care for people receiving outpatient treatment for alcohol dependence or alcohol-related harmful drinking. It may help by checking and improving how your liver health is supported while you stay in alcohol-use treatment.
KøgeAges 18–110 - NCT06629259RecruitingPhase 2
Guanfacine for Alcohol Use Disorder
This trial tests if guanfacine, a medication that calms certain brain signals, can help people reduce or stop drinking. You may qualify if you have moderate to severe alcohol use disorder and want to quit.
Indianapolis, IndianaAges 18 years+ - NCT07706660Recruiting
Mindfulness for alcohol use disorder treatment
This trial tests whether adding body-focused mindfulness exercises to standard inpatient treatment can help people with alcohol use disorder. It may improve your ability to manage cravings and prevent relapse.
Warsaw, MazovianAges 18 years+ - NCT07118839RecruitingPhase 2/Phase 3
MDMA therapy for veterans with PTSD and alcohol use
This study tests whether MDMA-assisted therapy can help veterans who have both PTSD and alcohol use disorder. If you have tried a standard therapy before and want to reduce or stop drinking, this treatment may offer a new option.
West Haven, ConnecticutAges 18 years+ - NCT07040592RecruitingPhase 2
Semaglutide for HIV and alcohol use
This study is testing whether semaglutide, a medication already used for diabetes and weight loss, can help people with HIV who also have an alcohol use disorder cut back on drinking. It is for patients treated at the Atlanta VA Healthcare System.
Decatur, GeorgiaAges 18–99 - NCT06823453Recruiting
Training friends and family to support people who use opioids
This study trains friends and family members of people who use opioids, so they can provide better support and reduce stigma. It also includes people who use opioids to see if this training improves their relationship and well-being.
Chicago, IllinoisAges 18 years+ - NCT06372899Recruiting
Switching to E-cigarettes or Nicotine Pouches for Smokers
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
Philadelphia, PennsylvaniaAges 21 years+ - NCT04793685RecruitingPhase 2
Prazosin for alcohol withdrawal symptoms in alcohol use disorder
This study tests whether prazosin can reduce symptoms that happen when someone stops or cuts back on heavy drinking. It may help people with moderate-to-severe alcohol use disorder who also have alcohol withdrawal symptoms.
New Haven, ConnecticutAges 18–70 - NCT06838468Enrolling by invitation
Study on liver health in alcohol detox patients
This study is looking at liver health in people staying in a detox unit for alcohol use disorder. Researchers want to see how common liver problems are in this group. Participating involves extra tests like blood work, an ultrasound, and a special liver scan (FibroScan).
Sabadell, BarcelonaAges 18–75 - NCT06349083RecruitingPhase 2
Psilocybin-assisted treatment for alcohol use disorder
This study tests whether psilocybin, a psychedelic drug, combined with therapy can help people reduce or stop drinking. It aims to understand how psilocybin affects the brain and behavior in people with alcohol use disorder.
New York, New YorkAges 18–65 - NCT05943665RecruitingPhase 2
MDMA-assisted therapy for PTSD and alcohol use in veterans
This study tests whether MDMA, given in a controlled clinical setting, can reduce symptoms of PTSD and alcohol use disorder in veterans. It also combines the medication with structured therapy sessions to help you manage symptoms without relying on alcohol or other substances.
Providence, Rhode IslandAges 18 years+ - NCT06115746Recruiting
A drug education program for middle and high school students
This study tests a program called iDECIDE, which helps students who have had a substance use issue at school. The program aims to provide education and support instead of punishment. Participants will attend up to 9 online study visits over about a year.
Boston, MassachusettsAges 9–22 - NCT07199517Recruiting
Helping smokers who aren't ready to quit
This study tests whether switching to a less harmful nicotine product (like a nicotine pouch or e-cigarette) can help people who are not ready to quit smoking reduce their health risks. You would be given a sample of a harm reduction product to try, and researchers will check how it affects your smoking habits.
Philadelphia, PennsylvaniaAges 21 years+
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Common questions
- Are there clinical trials for alcohol; harmful use?
- Yes. Clin2 currently lists 20 recruiting alcohol; harmful use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a alcohol; harmful use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a alcohol; harmful use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.