Pregnenolone treatment for alcohol use disorder
Treatments studied
Part of Mental health clinical trials.
This Phase 2 study tests pregnenolone to help reduce or improve alcohol use disorder symptoms. It looks for adults who drink regularly and meet diagnostic criteria for moderate to severe alcohol use disorder, while excluding people with certain other substance use, medicines, or serious mental/medical conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 to 70 years old, and you can read English for study visits and forms
- You’ve been drinking alcohol regularly (at least 3 days per week) before starting the study
- A clinician will confirm you meet DSM-5 criteria for moderate to severe alcohol use disorder (through an interview)
- You cannot currently have a moderate-to-severe addiction to other drugs (nicotine and cannabis can be allowed)
- You must not be taking certain medicines (like opioids or regular sedatives/anticonvulsants) and must be medically stable for the study
- If you can become pregnant: you must not be pregnant or nursing, and you must use reliable birth control during the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests a brief medication approach meant to reduce “problem drinking.” It may help people cut back or stop alcohol use by adjusting brain signaling related to drinking cravings and urges.
This Phase 1 study tests whether spironolactone (a medicine that affects salt and hormone balance) is safe and potentially helpful in people with alcohol use disorder. You may be eligible if you are currently drinking heavily, have low alcohol withdrawal symptoms, and meet several lab and medication safety rules.
This study tests whether a pill called apremilast can help reduce drinking in people with alcohol use disorder. You'll take the medication and attend regular visits to see how it affects your alcohol cravings and use.
This study tests whether brexpiprazole can help adults with alcohol use disorder. You must currently not be taking alcohol-focused treatment or alcohol medicines, and you’ll likely complete questionnaires and brain scans.
This trial tests two psychedelic-assisted therapies, psilocybin and ketamine, to see which works better for reducing heavy drinking in people with alcohol use disorder (AUD). You'll receive either drug along with counseling, and the study monitors safety closely.
This trial tests how the medication acamprosate affects brain activity in people with moderate to severe alcohol use disorder. It may help researchers understand how this treatment works.
Hear when a new Alcohol Use Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.