Biologics clinical trials

Nucleoside therapy for telomere disorders

This trial tests a nucleoside therapy (dC/dT) for people with telomere biology disorders, which cause premature aging and problems like low blood counts, lung or liver issues. The goal is to see if the treatment can help manage these symptoms.

Gum Disease and Inflammation Study

This study looks at gum disease (periodontitis and gingivitis) and inflammation using blood and dental samples. It may help researchers understand how inflammation affects gum health.

a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers

Biologic treatment for bowel narrowing in Crohn’s disease

This trial studies biologic medicines to treat Crohn’s disease that causes bowel narrowing (“strictures”) without needing immediate surgery. It may help reduce symptoms and complications by targeting the immune-driven inflammation behind the narrowing.

Biologic drugs for allergic bronchopulmonary aspergillosis with asthma

This study tests if biologic drugs are safe and effective for people with allergic bronchopulmonary aspergillosis (ABPA) who also have severe asthma. It may help if you've had an asthma attack in the past year.

Choosing the best first biologic for moderate to severe colitis

This study compares two first-line biologic drugs for moderate to severe ulcerative colitis to see which works better and why. The goal is to help find the best biologic treatment for each patient.

A study collecting samples from children with bone problems

This study collects blood and tissue samples from children with bone or growth plate problems to build a research database. It aims to better understand these conditions and may help improve future treatments.

Testing a new dialysis option for low blood pressure

This study tests a new dialysis option called 'Biologic Fusion' that may help people who often have low blood pressure during dialysis. It compares this new method to standard dialysis to see if it is safer and works better.

Enhancing the Clinical Management of CMF Through a National Pediatric and Adult Network Based on Biological and Genetic Data

Study of genes in MRKH syndrome and related families

This study looks at DNA (your genes) to better understand Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. It may help researchers learn more about the condition, and it can include both people with MRKH and healthy family relatives.

Build a hospital database of people in intensive care

This trial collects information about adults receiving intensive care to build a “database” that helps doctors and researchers better understand ICU patients. It mainly involves registering your clinical and health details, even if your condition is complex or you are getting comfort-focused care.

Test whether a lung ultrasound helps discharge planning after heart failure

This study looks at people hospitalized for worsening heart failure with weaker pumping (reduced ejection fraction). It tests whether a lung ultrasound evaluation near discharge can improve how doctors decide it is safe to send you home.

Hospital study for fluid buildup in heart failure with preserved heart function

This study looks at how well doctors can assess fluid buildup before you leave the hospital if you have a type of heart failure called “preserved ejection fraction.” It may help improve decisions about when and how safely people are discharged.

Biobank for urological and cancer research

This study collects blood, urine, and tissue samples from patients with urological diseases or cancers to build a biobank for future research. It may help researchers better understand these conditions and develop new treatments.

Collecting blood and tumor samples for cancer research

This study collects and stores tumor and blood samples from children and young adults with cancer, blood disorders, or immune conditions. The samples are used to better understand these diseases and could help future treatments.

Biologic and targeted therapy registry for arthritis patients

This registry is collecting information about people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis who are starting or needing biologic or targeted medicines. It may help researchers better understand how these treatments work in real life.

Severe nasal polyps: links between symptoms, tissue, and blood

This study looks at people with severe nasal polyps that need surgery (ethmoidectomy) for the first time. Researchers want to understand the connection between your symptoms, nasal tissue, and blood tests.

Biologics for asthma and COPD

This study looks at how well medicines called biologics work for people with asthma or COPD. Biologics are special shots that target certain parts of the immune system to reduce inflammation. Researchers want to see if these treatments can help control symptoms and prevent flare-ups.

Synthetic vascular graft for dialysis access

This trial tests a new synthetic blood vessel graft that connects an artery to a vein in your arm to create a reliable spot for dialysis. It's for people with kidney failure who need long-term dialysis but can't have the usual fistula made from their own blood vessels.

Genetic study of brain lesions

This trial looks at the genetic and molecular features of brain lesions to better understand them. It may help find new ways to diagnose or treat these conditions.

Digital tools to predict Alzheimer's risk factors

This study uses smartphone tools to track early signs of Alzheimer's by analyzing risk factors. It is for people with mild cognitive issues (MCI) or subjective cognitive decline (SCD) who do not have dementia.

Collecting samples to improve echinococcosis testing

This study collects tissue and blood samples from people having surgery for echinococcosis. The samples will help develop a better PCR test (a lab test that detects the parasite) so doctors can diagnose the infection more accurately.

Slowing aging through comprehensive health screening and interventions

This study helps healthy older adults understand their biological age—how old your body actually is—and tests personalized interventions to help you age more slowly and stay healthier longer. Researchers will perform detailed health assessments and then guide you through targeted treatments based on your individual aging profile.

Dietary supplement study on aging markers and body health

This study tests whether a dietary supplement containing humic and fulvic acids (natural compounds) can improve markers of biological aging, inflammation, and how your body handles toxins. Researchers will check blood samples to see if the supplement affects these markers over time.