Clinical trials
Borderline Personality Disorder clinical trials
Below are recruiting borderline personality disorder clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04870255Recruiting
Brain stimulation for depression in borderline personality disorder
This study tests a type of brain stimulation called rTMS to see if it can help improve mood in people who have both depression and borderline personality disorder. It may offer a new treatment option for those who haven't tried TMS before.
Stanford, CaliforniaAges 18–80 - NCT07460947RecruitingPhase 1/Phase 2
One-day TMS and medicine for suicidal thoughts in BPD
This trial tests if a single day of accelerated transcranial magnetic stimulation (TMS) combined with the medication D-cycloserine can reduce suicidal thoughts in people with borderline personality disorder (BPD). It aims to find a fast-acting treatment option for those who are struggling.
Belmont, MassachusettsAges 18 years+ - NCT07569198RecruitingPhase 2
Ketamine plus therapy for depression with suicidal thoughts
This study tests whether ketamine (a medication) combined with a specific type of therapy called DBT can help people with treatment-resistant depression and borderline personality disorder who are having thoughts of suicide. You would receive ketamine infusions alongside structured therapy sessions over 6 months.
Toronto, OntarioAges 18–70 - NCT03994510Recruiting
Study of shame in borderline personality disorder
This study looks at how people with borderline personality disorder experience shame and how that relates to symptoms and behavior. The goal is to better understand shame so future treatments can be more targeted.
Montpellier, HéraultAges 18 years+ - NCT04211753Recruiting
Mobile app support for emotional crises in borderline personality disorder
This study tests whether a smartphone app (B·RIGHT) can help people manage emotional crises related to borderline personality disorder, and checks that it is safe. If you match the diagnosis and age range, the app may be offered as part of the research.
Mataró, BarcelonaAges 18–60 - NCT04296604Recruiting
tDCS brain stimulation to improve thinking and mood
This study tests whether a non-surgical brain stimulation called tDCS can improve “executive function,” which means skills like planning, focus, and decision-making. It is designed for people with several mental health and substance-use conditions, and it may help you if those skills are affected by your diagnosis.
Boston, MassachusettsAges 18–65 - NCT04852744Recruiting
Brain scan study in teens with borderline and/or PTSD
This study uses brain imaging (MRI) to compare brain patterns in teens with borderline personality disorder and those with PTSD, as well as teens without these mental health diagnoses. It may help researchers understand what brain differences go along with these conditions and how they relate to each other.
CaenAges 13–18 - NCT05246527Recruiting
Exercise study to see effects in borderline personality disorder
This study looks at how a physical exercise session affects thinking and other outcomes in people diagnosed with borderline personality disorder. It may help researchers understand whether exercise has short-term benefits or risks for this group.
Bonn, North Rhine-WestphaliaAges 18–50 - NCT05651295Recruiting
Smartphone precision study to improve emotion regulation
This trial tests a precision approach delivered through a smartphone to better track and target how you manage strong emotions. It may help if you have ongoing difficulty regulating emotions day to day.
Columbus, OhioAges 18 years+ - NCT05698589Recruiting
Therapy program to reduce self-stigma in mental health
This study looks at how a program may help people with long-term mental health conditions feel less shame about their diagnosis (self-stigma). It is meant for adults who are stable enough to participate and who speak French.
BordeauxAges 18 years+ - NCT05712057Recruiting
Brain stimulation vs therapy for emotion regulation problems
This trial compares a type of brain stimulation (rTMS) to therapy to help people better manage strong emotions. You may be eligible if you have ongoing difficulties with emotion control and meet specific mood, anxiety, or related symptom criteria.
Durham, North CarolinaAges 18–55 - NCT05765864Recruiting
Study of self-harm in at-risk teens
This study looks at self-harm and thoughts/behaviors related to safety in teenagers who are considered at higher risk. It may help researchers better understand what supports are needed for teens who self-harm without wanting to die.
LjubljanaAges 13–18 - NCT05800925Recruiting
Triage survey to check who can join psychiatry research
This study uses a short questionnaire to figure out who is eligible to join future psychiatry research. It may help people get routed into studies that match their situation and safety needs.
Boston, MassachusettsAges 18 years+ - NCT05913544Recruiting
Integrative therapy for young adults with borderline personality disorder
This trial tests a short integrative therapy program along with repeated thinking (neurocognitive) and mental health assessments for young adults with borderline personality disorder (BPD). It may help improve symptoms and cognitive functioning by combining structured therapy and targeted evaluations.
NîmesAges 16–25 - NCT05942651Recruiting
tMS for impulsivity in borderline personality disorder
This trial studies whether magnetic brain stimulation (tMS) can reduce impulsive symptoms in people with borderline personality disorder. It may help by changing how brain networks involved in impulse control work.
Bron, AURAAges 18 years+ - NCT06018272Recruiting
Mentalization therapy for borderline personality disorder
This trial compares a therapy called mentalization-based treatment with other proven therapies for people with borderline personality disorder. It aims to find out which approach works better for reducing self-harm and suicidal behaviors.
BerlinAges 18–65 - NCT06106555Recruiting
What helps in DBT for borderline personality disorder
This study looks at what helps people get better from Dialectical Behaviour Therapy (DBT) for borderline personality disorder. It will track factors like self-harm and therapy progress to understand what works best.
Lund, Skåne CountyAges 18 years+ - NCT06446765RecruitingPhase 2
Mindfulness and brain feedback to boost BPD therapy
This study tests whether combining mindfulness training with brain scan feedback (neurofeedback) can improve the benefits of regular talk therapy for adults with borderline personality disorder. It takes place at Yale University.
New Haven, ConnecticutAges 18–60 - NCT06458933RecruitingPhase 2
Couples therapy for borderline personality disorder
This study tests talk therapy for couples where one person has borderline personality disorder (BPD). It aims to see if the therapy helps improve symptoms and relationship quality.
Toronto, CaliforniaAges 19 years+ - NCT06493708Recruiting
EMDR Therapy for Borderline Personality Disorder
This study tests whether Eye Movement Desensitization and Reprocessing (EMDR) therapy can help people with Borderline Personality Disorder (BPD). EMDR is a type of talk therapy often used for trauma, and this trial wants to see if it can improve BPD symptoms.
Brescia, BresciaAges 18–65 - NCT06563466Recruiting
Pegasus: Better treatment for emotional instability
This study tests a new way to treat emotionally unstable personality disorder (also called borderline personality disorder) by including family or close friends in therapy. It aims to see if this approach improves how patients feel and function.
CopenhagenAges 18 years+ - NCT06606002Recruiting
Group therapy for borderline symptoms in teens
This study tests if group schema therapy helps teenagers reduce borderline personality symptoms. It may be a good option if you have some borderline traits and can attend group sessions in Finnish.
Turku, Southwest FinlandAges 15–18 - NCT06683014RecruitingPhase 2
MDMA study for borderline personality disorder
This trial tests if a single dose of MDMA, given under supervision, can help people with borderline personality disorder (BPD). You will stay overnight after the session and be followed up for two weeks.
New Haven, ConnecticutAges 18–60 - NCT06772831Recruiting
Cognitive reappraisal training for borderline personality
This study tests a thinking strategy called 'cognitive reappraisal training' for people with borderline personality disorder (BPD). The goal is to see if this training helps manage emotions and symptoms related to BPD.
New York, New YorkAges 18–55
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Borderline Personality Disorder trials by city
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Borderline Personality Disorder trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for borderline personality disorder?
- Yes. Clin2 currently lists 44 recruiting borderline personality disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a borderline personality disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a borderline personality disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.