Clinical trials
Chronic Low Back Pain clinical trials
Below are recruiting chronic low back pain clinical trials, each written for real people, not researchers. We’re tracking 269 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07876960Recruiting
Virtual reality games versus spinal adjustment for chronic back pain
This study compares two treatments for chronic low back pain: playing interactive virtual reality games and receiving spinal manipulation (a hands-on adjustment by a therapist). It aims to see which approach helps reduce pain and improve daily function.
Giza, Giza GovernorateAges 20–55 - NCT04704297RecruitingPhase 4
Trigger point shots for low back muscle pain
This trial tests whether injecting sore “trigger points” in low back muscles helps improve chronic low back pain. It compares treatments in people with specific low back muscle pain patterns and excludes several other causes of pain.
Tacoma, WashingtonAges 18 years+ - NCT04631133Recruiting
Study of outcomes after surgery using the LISA implant
This study follows adults who get back surgery using the LISA implant to see how well they do afterward and how outcomes change over time. It focuses on people whose long-term, non-surgical care did not relieve low-back pain from specific age-related disc changes.
SilkeborgAges 18 years+ - NCT05963451Recruiting
Testing treatments for long-term low back pain from facet joints
This study focuses on people with long-lasting low back pain that likely comes from the small “facet” joints in the lower spine. It aims to better understand brain, psychological, and biology changes to help optimize treatment for this type of back pain.
Sherbrooke, QuebecAges 18–75 - NCT04783454Recruiting
Preventing neck and back pain in teleworkers
This study tests ways to prevent neck and back pain in people who work at a computer from home or an office. If you qualify, you may be assigned to an intervention aimed at reducing pain and improving comfort.
Ghent, East FlandersAges 18–69 - NCT05986370Recruiting
Study on back pain and spinal manipulation
This trial tests whether spinal manipulation therapy (a type of hands-on treatment) can help people with long-term low back pain. It also compares their results to healthy volunteers of the same age and sex.
Trois-Rivières, QuebecAges 18–60 - NCT05757609Recruiting
Brain stimulation therapy for chronic low back pain
This trial tests whether a non-invasive brain stimulation treatment can improve physiotherapy results for people with long-lasting low back pain. You may be asked to do questionnaires and follow a treatment plan, and some people may be able to reduce pain or improve function.
GenevaAges 18–65 - NCT04853732Recruiting
Pain research registry for chronic low back pain
This study is a research registry that collects information from people with chronic low back pain (and some people without chronic pain). It may help researchers better understand pain patterns and guide future treatments.
Fort Worth, TexasAges 21–79 - NCT07856498Recruiting
Understanding pain and movement in postmenopausal women with low back pain
This study looks at how thoughts and fears about pain affect physical activity in women after menopause who have chronic low back pain. The goal is to learn more about these connections to help improve future treatments.
Istanbul, IstanbulAges 45–65 - NCT07860697Recruiting
MRI study of back pain and spine changes
This study looks at MRI images of the lower back to see how body fat, back muscles, and small spine joints relate to long-term back pain. It may help doctors understand back pain better and improve future treatments.
Istanbul, IstanbulAges 18–75 - NCT06361485RecruitingPhase 1
Umbilical cord injection for chronic low back pain
This study tests whether a special injection made from umbilical cord tissue is safe and can help with long-term low back pain. It is for adults who have not had recent back procedures or certain health problems.
Scottsdale, ArizonaAges 20 years+ - NCT07846163Recruiting
Pain assessment for chronic low back pain
This study looks at how the brain and nervous system process pain in people with long-lasting low back pain. It uses safe measurements inside a shielded room to compare chronic pain patients with healthy people, which may help improve pain treatments.
Thessaloniki, Central MacedoniaAges 18–45 - NCT07836439Enrolling by invitation
Comparing two manual therapies for low back pain relief
This study compares two hands-on treatments, the Graston Technique and diacutaneous fibrolysis, to see which works better for reducing low back pain, improving function, and enhancing quality of life. If you have non-specific low back pain (pain without a clear cause), this trial may help you find a new way to manage your symptoms.
Sialkot, Punjab ProvinceAges 20–40 - NCT07826546Recruiting
Back pain sensitivity as a predictor of recovery
This study looks at whether increased sensitivity to pain in people with chronic low back pain might predict how well they recover. It aims to help doctors understand which treatments might work best for each person.
MardinAges 18–65 - NCT07832188Recruiting
Brain stimulation for chronic lower back pain
This study tests a non-invasive brain stimulation technique that uses gentle electrical currents to target the part of the brain involved in pain processing. It may help reduce chronic lower back pain that is not caused by a specific injury or condition.
Jinan, ShandongAges 18–80 - NCT07829289Enrolling by invitation
Ear acupressure for long-term back pain in postmenopausal women
This study tests whether applying pressure to specific points on the ear can reduce chronic low back pain in women who have gone through menopause. You would receive a simple, non-invasive treatment that you can do at home.
Kaohsiung City, Sanmin DistrictAges 50–65 - NCT06491121Recruiting
Can high-intensity training with a smartphone help chronic back pain?
This trial tests if a technology-supported high-intensity exercise program can help adults with chronic low back pain. You'll use your own smartphone to help guide the training and attend regular therapy sessions.
Wilrijk, AntwerpenAges 18–65 - NCT07814729Recruiting
Sacral block for chronic sacroiliac joint pain
This study tests whether adding a nerve block near the sacrum to a standard sacroiliac joint injection gives more pain relief. It's for people with long-term sacroiliac joint pain that hasn't improved with other treatments.
Al FayyumAges 21–60 - NCT07807839Recruiting
Back pain study: testing a blood protein linked to MRI findings
This study looks at how a protein in your blood (called BDNF) relates to the severity of your lower back condition, as seen on MRI. It may help doctors better understand and treat back pain in the future.
Daegu, DaeguAges 20–80 - NCT07776366Recruiting
Study of disc protein levels and disc wear
This study looks at a protein called periostin in the discs of the lower back to see if it relates to how worn down the discs are, which might help improve future treatments.
Daegu, DaeguAges 20–80 - NCT07776379Recruiting
Predicting recovery with BDNF blood levels in chronic low back pain
This study looks at whether a protein in your blood, called BDNF, can help predict how well you might do with chronic low back pain. By participating, you may help doctors better understand and treat this condition.
Daegu, DaeguAges 20–80 - NCT05752396Recruiting
Study of Pain Patterns Over Time in Kids
This study follows kids who have a specific type of chronic pain (headaches, stomach pain, or muscle/joint pain) to better understand how pain changes over time. It also checks whether certain factors are linked to those pain patterns.
Cincinnati, OhioAges 10–19 - NCT07772141Recruiting
Palmitoylethanolamide for chronic low back pain
This trial tests whether a natural substance called palmitoylethanolamide (PEA) can help reduce chronic low back pain by calming the nervous system and reducing inflammation. It might be an option for people with ongoing pain from a disc problem who haven't had surgery.
Banī SuwayfAges 18–65 - NCT07764354Recruiting
Patient education for sticking with home exercises
This study tests whether extra education helps people with chronic musculoskeletal conditions—like long-term back pain, knee arthritis, or partial rotator cuff tears—stick with their home exercise routines to feel better. If you have one of these conditions and are willing to follow a home exercise plan, this could help you manage pain.
Dammam, Eastern ProvinceAges Any age
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Chronic Low Back Pain trials by city
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Chronic Low Back Pain trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for chronic low back pain?
- Yes. Clin2 currently lists 269 recruiting chronic low back pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic low back pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic low back pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.